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Items: 16


Topoisomerases I and III inhibit R-loop formation to prevent unregulated replication in the chromosomal Ter region of Escherichia coli.

Brochu J, Vlachos-Breton É, Sutherland S, Martel M, Drolet M.

PLoS Genet. 2018 Sep 17;14(9):e1007668. doi: 10.1371/journal.pgen.1007668. eCollection 2018 Sep.


Investigating direct interaction between Escherichia coli topoisomerase I and RecA.

Banda S, Tiwari PB, Darici Y, Tse-Dinh YC.

Gene. 2016 Jul 1;585(1):65-70. doi: 10.1016/j.gene.2016.03.013. Epub 2016 Mar 19.


Structural basis for suppression of hypernegative DNA supercoiling by E. coli topoisomerase I.

Tan K, Zhou Q, Cheng B, Zhang Z, Joachimiak A, Tse-Dinh YC.

Nucleic Acids Res. 2015 Dec 15;43(22):11031-46. doi: 10.1093/nar/gkv1073. Epub 2015 Oct 20.


Antimicrobial Susceptibility and SOS-Dependent Increase in Mutation Frequency Are Impacted by Escherichia coli Topoisomerase I C-Terminal Point Mutation.

Yang J, Annamalai T, Cheng B, Banda S, Tyagi R, Tse-Dinh YC.

Antimicrob Agents Chemother. 2015 Oct;59(10):6195-202. doi: 10.1128/AAC.00855-15. Epub 2015 Jul 27.


Dependence of transcription-coupled DNA supercoiling on promoter strength in Escherichia coli topoisomerase I deficient strains.

Zhi X, Leng F.

Gene. 2013 Feb 10;514(2):82-90. doi: 10.1016/j.gene.2012.11.011. Epub 2012 Nov 29.


Bacterial topoisomerase I and topoisomerase III relax supercoiled DNA via distinct pathways.

Terekhova K, Gunn KH, Marko JF, Mondragón A.

Nucleic Acids Res. 2012 Nov 1;40(20):10432-40. doi: 10.1093/nar/gks780. Epub 2012 Aug 25.


On the viability of Escherichia coli cells lacking DNA topoisomerase I.

Stockum A, Lloyd RG, Rudolph CJ.

BMC Microbiol. 2012 Feb 28;12:26. doi: 10.1186/1471-2180-12-26.


Asp-to-Asn substitution at the first position of the DxD TOPRIM motif of recombinant bacterial topoisomerase I is extremely lethal to E. coli.

Cheng B, Annamalai T, Sorokin E, Abrenica M, Aedo S, Tse-Dinh YC.

J Mol Biol. 2009 Jan 16;385(2):558-67. doi: 10.1016/j.jmb.2008.10.073. Epub 2008 Nov 5.


Depletion of RNase HI activity in Escherichia coli lacking DNA topoisomerase I leads to defects in DNA supercoiling and segregation.

Usongo V, Nolent F, Sanscartier P, Tanguay C, Broccoli S, Baaklini I, Drlica K, Drolet M.

Mol Microbiol. 2008 Aug;69(4):968-81. doi: 10.1111/j.1365-2958.2008.06334.x. Epub 2008 Jun 28.


Differential regulation of Escherichia coli topoisomerase I by Fis.

Weinstein-Fischer D, Altuvia S.

Mol Microbiol. 2007 Feb;63(4):1131-44.


Bacterial cell killing mediated by topoisomerase I DNA cleavage activity.

Cheng B, Shukla S, Vasunilashorn S, Mukhopadhyay S, Tse-Dinh YC.

J Biol Chem. 2005 Nov 18;280(46):38489-95. Epub 2005 Sep 13.


Viability of Escherichia coli topA mutants lacking DNA topoisomerase I.

Stupina VA, Wang JC.

J Biol Chem. 2005 Jan 7;280(1):355-60. Epub 2004 Nov 1.


RNase HI overproduction is required for efficient full-length RNA synthesis in the absence of topoisomerase I in Escherichia coli.

Baaklini I, Hraiky C, Rallu F, Tse-Dinh YC, Drolet M.

Mol Microbiol. 2004 Oct;54(1):198-211.


Complete nucleotide sequence of the topA gene encoding Escherichia coli DNA topoisomerase I.

Tse-Dinh YC, Wang JC.

J Mol Biol. 1986 Oct 5;191(3):321-31.


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