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Signaling through the adaptor molecule MyD88 in CD4+ T cells is required to overcome suppression by regulatory T cells.

Schenten D, Nish SA, Yu S, Yan X, Lee HK, Brodsky I, Pasman L, Yordy B, Wunderlich FT, Brüning JC, Zhao H, Medzhitov R. Schenten D, et al. Immunity. 2014 Jan 16;40(1):78-90. doi: 10.1016/j.immuni.2013.10.023. Immunity. 2014. PMID: 24439266 Free PMC article.

Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice.

Hua Z, Gross AJ, Lamagna C, Ramos-Hernández N, Scapini P, Ji M, Shao H, Lowell CA, Hou B, DeFranco AL. Hua Z, et al. J Immunol. 2014 Feb 1;192(3):875-85. doi: 10.4049/jimmunol.1300683. Epub 2013 Dec 30. J Immunol. 2014. PMID: 24379120 Free PMC article.

MyD88 signaling regulates both host defense and immunopathogenesis during pneumocystis infection.

Bello-Irizarry SN, Wang J, Johnston CJ, Gigliotti F, Wright TW. Bello-Irizarry SN, et al. J Immunol. 2014 Jan 1;192(1):282-92. doi: 10.4049/jimmunol.1301431. Epub 2013 Nov 29. J Immunol. 2014. PMID: 24293628 Free PMC article.

Intracellular Shigella remodels its LPS to dampen the innate immune recognition and evade inflammasome activation.

Paciello I, Silipo A, Lembo-Fazio L, Curcurù L, Zumsteg A, Noël G, Ciancarella V, Sturiale L, Molinaro A, Bernardini ML. Paciello I, et al. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):E4345-54. doi: 10.1073/pnas.1303641110. Epub 2013 Oct 28. Proc Natl Acad Sci U S A. 2013. PMID: 24167293 Free PMC article.

Deficiency of the myeloid differentiation primary response molecule MyD88 leads to an early and rapid development of Helicobacter-induced gastric malignancy.

Banerjee A, Thamphiwatana S, Carmona EM, Rickman B, Doran KS, Obonyo M. Banerjee A, et al. Infect Immun. 2014 Jan;82(1):356-63. doi: 10.1128/IAI.01344-13. Epub 2013 Oct 28. Infect Immun. 2014. PMID: 24166959 Free PMC article.

MYD88 (L265P) mutation is an independent risk factor for progression in patients with IgM monoclonal gammopathy of undetermined significance.

Varettoni M, Zibellini S, Arcaini L, Boveri E, Rattotti S, Pascutto C, Mangiacavalli S, Gotti M, Pochintesta L, Paulli M, Cazzola M. Varettoni M, et al. Blood. 2013 Sep 26;122(13):2284-5. doi: 10.1182/blood-2013-07-513366. Blood. 2013. PMID: 24072850 Free article. No abstract available.

Mutational analysis identifies residues crucial for homodimerization of myeloid differentiation factor 88 (MyD88) and for its function in immune cells.

Loiarro M, Volpe E, Ruggiero V, Gallo G, Furlan R, Maiorino C, Battistini L, Sette C. Loiarro M, et al. J Biol Chem. 2013 Oct 18;288(42):30210-30222. doi: 10.1074/jbc.M113.490946. Epub 2013 Sep 9. J Biol Chem. 2013. PMID: 24019529 Free PMC article.

Mycobacteria-infected dendritic cells attract neutrophils that produce IL-10 and specifically shut down Th17 CD4 T cells through their IL-10 receptor.

Doz E, Lombard R, Carreras F, Buzoni-Gatel D, Winter N. Doz E, et al. J Immunol. 2013 Oct 1;191(7):3818-26. doi: 10.4049/jimmunol.1300527. Epub 2013 Aug 30. J Immunol. 2013. PMID: 23997221

Hypothalamo-pituitary and immune-dependent adrenal regulation during systemic inflammation.

Kanczkowski W, Alexaki VI, Tran N, Großklaus S, Zacharowski K, Martinez A, Popovics P, Block NL, Chavakis T, Schally AV, Bornstein SR. Kanczkowski W, et al. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14801-6. doi: 10.1073/pnas.1313945110. Epub 2013 Aug 19. Proc Natl Acad Sci U S A. 2013. PMID: 23959899 Free PMC article.

MYD88 L265P somatic mutation: its usefulness in the differential diagnosis of bone marrow involvement by B-cell lymphoproliferative disorders.

Ondrejka SL, Lin JJ, Warden DW, Durkin L, Cook JR, Hsi ED. Ondrejka SL, et al. Am J Clin Pathol. 2013 Sep;140(3):387-94. doi: 10.1309/AJCP10ZCLFZGYZIP. Am J Clin Pathol. 2013. PMID: 23955458

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