Abstract
The rat homologue of the gene encoding the fibroblast growth factor receptor subtype 4 (FGFR4) was cloned from rat lung mRNA, and the cDNA sequence was found to be 95% similar and 92% identical to the human homologue. Northern blot analysis of adult rat tissues demonstrated that a 3.1-kb mRNA encoding FGFR4 is detectable only in the lung and kidney. The receptor variant described here encodes two potential immunoglobulin-like domains, 21 hydrophobic amino acids encoding a potential transmembrane domain, and a split tyrosine kinase motif. However, the acidic box and hydrophobic signal peptide domains are not present in this cDNA isolate.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Blotting, Northern
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Chickens
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Cloning, Molecular
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DNA / genetics
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DNA / isolation & purification
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Gene Expression
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Genetic Variation
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Humans
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Lung / physiology
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Molecular Sequence Data
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Open Reading Frames
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Organ Specificity
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RNA, Messenger / analysis
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RNA, Messenger / genetics
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Rats
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Receptors, Fibroblast Growth Factor / classification
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Receptors, Fibroblast Growth Factor / genetics*
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Sequence Homology, Nucleic Acid
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Transcription, Genetic
Substances
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RNA, Messenger
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Receptors, Fibroblast Growth Factor
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DNA
Associated data
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GENBANK/M79310
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GENBANK/M91599
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GENBANK/X65106
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GENBANK/X65107
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GENBANK/X65108
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GENBANK/X65109
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GENBANK/X65110
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GENBANK/X65111
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GENBANK/X65112
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GENBANK/X65113