Abstract
In addition to the two previously identified genes rearranged and expressed in a cytotoxic T-lymphocyte clone, we have identified a third gene that is also rearranged and expressed in the same clone. This new gene shows clonal diversity, codes for a polypeptide chain that contains immunoglobulin-like variable and constant domains, carries potential N-glycosylation sites and is a particularly attractive candidate for the gene that encodes the alpha-subunit of the heterodimeric antigen receptor of this T-cell clone.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Cell Line
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Clone Cells
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Cloning, Molecular*
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DNA / analysis
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Genes*
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Humans
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Immunoglobulins / genetics
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Macromolecular Substances
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Mice
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Poly A / genetics
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RNA / genetics
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RNA, Messenger
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Receptors, Antigen, T-Cell / genetics*
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T-Lymphocytes, Cytotoxic / immunology*
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Transcription, Genetic
Substances
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Immunoglobulins
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Macromolecular Substances
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RNA, Messenger
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Receptors, Antigen, T-Cell
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Poly A
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RNA
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DNA