PubMed (RefSeq) for id: 1720386589

Year	Number of Results
1998	4
1999	2
2000	6
2001	6
2002	6
2003	9
2004	11
2005	13
2006	19
2007	9
2008	8
2009	16
2010	17
2011	17
2012	15
2013	10
2014	7
2015	9
2016	7
2017	9
2018	11
2019	10
2020	11
2021	10
2022	7
2023	7
2024	2

1

Pregnane X receptor knockout mitigates weight gain and hepatic metabolic dysregulation in female C57BL/6 J mice on a long-term high-fat diet.

Gebreyesus LH, Choi S, Neequaye P, Mahmoud M, Mahmoud M, Ofosu-Boateng M, Twum E, Nnamani DO, Wang L, Yadak N, Ghosh S, Gonzalez FJ, Gyamfi MA. Gebreyesus LH, et al. Biomed Pharmacother. 2024 Apr;173:116341. doi: 10.1016/j.biopha.2024.116341. Epub 2024 Feb 29. Biomed Pharmacother. 2024. PMID: 38428309 Free article.

2

S-nitrosylation attenuates pregnane X receptor hyperactivity and acetaminophen-induced liver injury.

Cui Q, Jiang T, Xie X, Wang H, Qian L, Cheng Y, Li Q, Lu T, Yao Q, Liu J, Lai B, Chen C, Xiao L, Wang N. Cui Q, et al. JCI Insight. 2024 Jan 23;9(2):e172632. doi: 10.1172/jci.insight.172632. JCI Insight. 2024. PMID: 38032737 Free PMC article.

3

Mice lacking intestinal Nr1i2 have normal intestinal homeostasis under steady-state conditions and are not hypersensitive to inflammation under lipopolysaccharide treatment.

Amini SE, Bresson SE, Ruzzin J. Amini SE, et al. FASEB J. 2023 Aug;37(8):e23117. doi: 10.1096/fj.202301126. FASEB J. 2023. PMID: 37490003

4

Pregnane X receptor activation remodels glucose metabolism to promote NAFLD development in obese mice.

Karpale M, Kummu O, Kärkkäinen O, Lehtonen M, Näpänkangas J, Herfurth UM, Braeuning A, Rysä J, Hakkola J. Karpale M, et al. Mol Metab. 2023 Oct;76:101779. doi: 10.1016/j.molmet.2023.101779. Epub 2023 Jul 17. Mol Metab. 2023. PMID: 37467962 Free PMC article.

5

Pregnane X receptor activation alleviates renal fibrosis in mice via interacting with p53 and inhibiting the Wnt7a/β-catenin signaling.

Ming WH, Luan ZL, Yao Y, Liu HC, Hu SY, Du CX, Zhang C, Zhao YH, Huang YZ, Sun XW, Qiao RF, Xu H, Guan YF, Zhang XY. Ming WH, et al. Acta Pharmacol Sin. 2023 Oct;44(10):2075-2090. doi: 10.1038/s41401-023-01113-7. Epub 2023 Jun 21. Acta Pharmacol Sin. 2023. PMID: 37344564

6

Pregnane X receptor (PXR) deficiency protects against spinal cord injury by activating NRF2/HO-1 pathway.

Xuan LN, Hu ZX, Jiang ZF, Zhang C, Sun XW, Ming WH, Liu HT, Qiao RF, Shen LJ, Liu SB, Wang GY, Wen L, Luan ZL, Yin J. Xuan LN, et al. CNS Neurosci Ther. 2023 Nov;29(11):3460-3478. doi: 10.1111/cns.14279. Epub 2023 Jun 2. CNS Neurosci Ther. 2023. PMID: 37269088 Free PMC article.

7

Oral arsenic administration to humanizedUDP-glucuronosyltransferase1 neonatal mice induces UGT1A1 through a dependence on Nrf2 and PXR.

Yang X, Weber AA, Mennillo E, Paszek M, Wong S, Le S, Teo JYA, Chang M, Benner CW, Tukey RH, Chen S. Yang X, et al. J Biol Chem. 2023 Mar;299(3):102955. doi: 10.1016/j.jbc.2023.102955. Epub 2023 Jan 30. J Biol Chem. 2023. PMID: 36720308 Free PMC article.

8

PXR triggers YAP-TEAD binding and Sirt2-driven YAP deacetylation and polyubiquitination to promote liver enlargement and regeneration in mice.

Zhang S, Guo M, Jiang X, Tang L, Wu T, Bi G, Yang X, Fan S, Bi H. Zhang S, et al. Pharmacol Res. 2023 Feb;188:106666. doi: 10.1016/j.phrs.2023.106666. Epub 2023 Jan 16. Pharmacol Res. 2023. PMID: 36657504 Free article.

9

The Pregnane X Receptor and Indole-3-Propionic Acid Shape the Intestinal Mesenchyme to Restrain Inflammation and Fibrosis.

Flannigan KL, Nieves KM, Szczepanski HE, Serra A, Lee JW, Alston LA, Ramay H, Mani S, Hirota SA. Flannigan KL, et al. Cell Mol Gastroenterol Hepatol. 2023;15(3):765-795. doi: 10.1016/j.jcmgh.2022.10.014. Epub 2022 Oct 26. Cell Mol Gastroenterol Hepatol. 2023. PMID: 36309199 Free PMC article.

10

Pregnane X receptor promotes liver enlargement in mice through the spatial induction of hepatocyte hypertrophy and proliferation.

Tian J, Wang R, Yang X, Yang J, Zhang Y, Li X, Liang H, Fan S, Gao Y, Zhang S, Qu X, Huang M, Bi H. Tian J, et al. Chem Biol Interact. 2022 Nov 1;367:110133. doi: 10.1016/j.cbi.2022.110133. Epub 2022 Aug 27. Chem Biol Interact. 2022. PMID: 36030841

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