Parasiticidal 2-alkoxy- and 2-aryloxyiminoalkyl trifluoromethanesulfonanilides

Bioorg Med Chem Lett. 2008 Jan 1;18(1):252-5. doi: 10.1016/j.bmcl.2007.10.090. Epub 2007 Oct 30.

Abstract

A series of novel 2-alkoxy- and 2-aryloxyiminoalkyl trifluoromethanesulfonanilide derivatives have shown significant in vitro parasiticidal activity against the ectoparasites Ctenocephalides felis and Rhipicephalus sanguineus. A number of these compounds also displayed significant in vitro endoparasite activity against the nematode Haemonchus contortus.

MeSH terms

  • Animals
  • Antiparasitic Agents / chemistry*
  • Antiparasitic Agents / pharmacology*
  • Haemonchus / drug effects
  • Rhipicephalus sanguineus / drug effects*
  • Siphonaptera / drug effects*
  • Structure-Activity Relationship
  • Sulfonamides / chemistry*
  • Sulfonamides / pharmacology*

Substances

  • Antiparasitic Agents
  • Sulfonamides
  • trifluoromethanesulfonanilide