2-Aminoresorcinol is a potent alpha-glucosidase inhibitor

Hong Gao; Jun Kawabata

doi:10.1016/j.bmcl.2007.11.032

2-Aminoresorcinol is a potent alpha-glucosidase inhibitor

Bioorg Med Chem Lett. 2008 Jan 15;18(2):812-5. doi: 10.1016/j.bmcl.2007.11.032. Epub 2007 Nov 17.

Authors

Hong Gao¹, Jun Kawabata

Affiliation

¹ Laboratory of Food Biochemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan.

PMID: 18039578
DOI: 10.1016/j.bmcl.2007.11.032

Abstract

A series of aminoresorcinols and related compounds were tested for rat intestinal alpha-glucosidase inhibition and these results suggested that the 2-aminoresorcinol moiety of 6-amino-5,7-dihydroxyflavone (2) is important to exert the intestinal alpha-glucosidase inhibitory activity and 2-aminoresorcinol (4), itself, is a potent alpha-glucosidase inhibitor and inhibited sucrose-hydrolyzing activity of rat intestinal alpha-glucosidase uncompetitively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Enzyme Inhibitors / pharmacology*
Glycoside Hydrolase Inhibitors*
Intestines / enzymology
Rats
Resorcinols / chemistry*
Resorcinols / pharmacology

Substances

Enzyme Inhibitors
Glycoside Hydrolase Inhibitors
Resorcinols
resorcinol