New diterpene glycosides of the fungus Acremonium striatisporum isolated from a sea cucumber

Shamil Sh Afiyatullov; Anatoly I Kalinovsky; Tatyana A Kuznetsova; Vladimir V Isakov; Mikhail V Pivkin; Pavel S Dmitrenok; George B Elyakov

doi:10.1021/np010503y

New diterpene glycosides of the fungus Acremonium striatisporum isolated from a sea cucumber

J Nat Prod. 2002 May;65(5):641-4. doi: 10.1021/np010503y.

Authors

Shamil Sh Afiyatullov¹, Anatoly I Kalinovsky, Tatyana A Kuznetsova, Vladimir V Isakov, Mikhail V Pivkin, Pavel S Dmitrenok, George B Elyakov

Affiliation

¹ Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Vladivostok 22, Russian Federation.

PMID: 12027733
DOI: 10.1021/np010503y

Abstract

Three new diterpene glycosides, virescenosides O (1), P (2), and Q (3), have been isolated from a marine strain of Acremonium striatisporum KMM 4401 associated with the holothurian Eupentacta fraudatrix. Their structures were determined on the basis of HRMALDIMS and NMR data as beta-D-altropyranosido-19-isopimara-8(14),15-diene-7alpha,3beta-diol (1), beta-D-altropyranosido-19-7-oxoisopimara-8(9),15-diene-3beta-ol (2), and beta-D-mannopyranosido-19-isopimara-7,15-diene-3beta-ol (3). The cytotoxic activity of the virescenosides was examined.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Acremonium / chemistry*
Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Carcinoma, Ehrlich Tumor
Circular Dichroism
Diterpenes / chemistry
Diterpenes / isolation & purification*
Diterpenes / pharmacology
Glycosides / chemistry
Glycosides / isolation & purification*
Glycosides / pharmacology
Hydrolysis
Inhibitory Concentration 50
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Sea Cucumbers
Stereoisomerism

Substances

Antineoplastic Agents
Diterpenes
Glycosides
virescenoside O
virescenoside P
virescenoside Q