Abstract
Cladobotrin (1) and rubrobramide (2) were isolated from the culture filtrate of Cladobotryum rubrobrunnescens, a mycophilic deuteriomycete. Rubrobramide (2), possessing a unique oxidized tricyclic system, is a new compound structurally related to flavipucine (3), which also is produced by the fungus. The structure of 2 was determined by spectroscopic methods. Cladobotrin (1) exhibited weak nematicidal activity toward Meldogyne incognita, while 2 showed weak cytotoxic and phytotoxic activities.
MeSH terms
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Anti-Infective Agents / isolation & purification
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Anti-Infective Agents / pharmacology
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Antibiotics, Antineoplastic / isolation & purification*
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Antibiotics, Antineoplastic / pharmacology
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Antinematodal Agents / isolation & purification
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Antinematodal Agents / pharmacology
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Drug Screening Assays, Antitumor
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Ethers, Cyclic / isolation & purification*
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Ethers, Cyclic / pharmacology
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Ethers, Cyclic / toxicity
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Herbicides / isolation & purification*
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Herbicides / toxicity
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Humans
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Mitosporic Fungi / chemistry*
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Molecular Conformation
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Tumor Cells, Cultured
Substances
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Anti-Infective Agents
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Antibiotics, Antineoplastic
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Antinematodal Agents
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Ethers, Cyclic
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Herbicides
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rubrobramide