Abstract
A series of chlorinated bisindole pyrroles, lynamicins A-E (1-5), was discovered from a novel marine actinomycete, NPS12745, which was isolated from a marine sediment collected off the coast of San Diego, California. Close to full length 16S rRNA sequence analysis indicated that NPS12745 is a novel strain of a recently described marine actinomycete with the proposed genus name Marinispora. The antimicrobial spectrum of these compounds was evaluated against a panel of 11 pathogens, which demonstrated that these substances possess broad-spectrum activity against both Gram-positive and Gram-negative organisms. Significantly, compounds 1-5 were active against drug-resistant pathogens such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium.
MeSH terms
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Actinobacteria / chemistry*
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Actinobacteria / genetics
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology*
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California
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Drug Resistance, Bacterial / drug effects
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Enterococcus faecium / drug effects
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Gram-Negative Bacteria / drug effects*
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Gram-Positive Bacteria / drug effects*
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Hydrocarbons, Chlorinated / chemistry
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Hydrocarbons, Chlorinated / isolation & purification*
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Hydrocarbons, Chlorinated / pharmacology*
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Indoles / chemistry
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Indoles / isolation & purification*
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Indoles / pharmacology*
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Marine Biology
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Methicillin Resistance / drug effects
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Microbial Sensitivity Tests
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Molecular Structure
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Pyrroles / chemistry
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Pyrroles / isolation & purification*
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Pyrroles / pharmacology*
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Staphylococcus aureus / drug effects
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Vancomycin Resistance / drug effects
Substances
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Anti-Bacterial Agents
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Hydrocarbons, Chlorinated
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Indoles
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Pyrroles