Botcinins A, B, C, and D, metabolites produced by Botrytis cinerea, and their antifungal activity against Magnaporthe grisea, a pathogen of rice blast disease

J Nat Prod. 2005 Dec;68(12):1768-72. doi: 10.1021/np0503855.

Abstract

Four new metabolites, botcinins A-D, were isolated from the culture filtrate of a strain of Botrytis cinerea. Their structures were determined by spectroscopic methods, mainly NMR techniques, molecular modeling, and the modified Mosher's method. They exhibited antifungal activities against Magnaporthegrisea, a pathogen of rice blast disease. Botcinins B and C have a MIC of 12.5 microM, and botcinins A and D are not active below 100 microM.

MeSH terms

  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification*
  • Antifungal Agents / pharmacology
  • Botrytis / chemistry*
  • Dose-Response Relationship, Drug
  • Heterocyclic Compounds, 3-Ring / chemistry
  • Heterocyclic Compounds, 3-Ring / isolation & purification*
  • Heterocyclic Compounds, 3-Ring / pharmacology
  • Magnaporthe / drug effects*
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Oryza / microbiology*
  • Plant Diseases / microbiology*
  • Pyrones / chemistry
  • Pyrones / isolation & purification*
  • Pyrones / pharmacology

Substances

  • Antifungal Agents
  • Heterocyclic Compounds, 3-Ring
  • Pyrones