Abstract
Four new metabolites, botcinins A-D, were isolated from the culture filtrate of a strain of Botrytis cinerea. Their structures were determined by spectroscopic methods, mainly NMR techniques, molecular modeling, and the modified Mosher's method. They exhibited antifungal activities against Magnaporthegrisea, a pathogen of rice blast disease. Botcinins B and C have a MIC of 12.5 microM, and botcinins A and D are not active below 100 microM.
MeSH terms
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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Botrytis / chemistry*
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Dose-Response Relationship, Drug
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Heterocyclic Compounds, 3-Ring / chemistry
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Heterocyclic Compounds, 3-Ring / isolation & purification*
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Heterocyclic Compounds, 3-Ring / pharmacology
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Magnaporthe / drug effects*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Oryza / microbiology*
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Plant Diseases / microbiology*
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Pyrones / chemistry
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Pyrones / isolation & purification*
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Pyrones / pharmacology
Substances
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Antifungal Agents
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Heterocyclic Compounds, 3-Ring
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Pyrones