PubMed (MeSH Keyword) for id: 135743577

Year	Number of Results
2014	1
2017	3
2018	3
2019	2
2020	1
2021	2
2022	1
2024	0

1

SP2509, a Selective Inhibitor of LSD1, Suppresses Retinoblastoma Growth by Downregulating β-catenin Signaling.

Jiang A, Wu W, Xu C, Mao L, Ao S, Guo H, Sun X, Tao J, Sang Y, Huang G. Jiang A, et al. Invest Ophthalmol Vis Sci. 2022 Mar 2;63(3):20. doi: 10.1167/iovs.63.3.20. Invest Ophthalmol Vis Sci. 2022. PMID: 35297943 Free PMC article.

2

Intermolecular insights into allosteric inhibition of histone lysine-specific demethylase 1.

Zhang X, Sun Y, Zhang Z, Wang H, Wang J, Zhao D. Zhang X, et al. Biochim Biophys Acta Gen Subj. 2021 Nov;1865(11):129990. doi: 10.1016/j.bbagen.2021.129990. Epub 2021 Aug 12. Biochim Biophys Acta Gen Subj. 2021. PMID: 34390793

3

SP2509, an inhibitor of LSD1, exerts potential antitumor effects by targeting the JAK/STAT3 signaling.

Zhen H, Zhang X, Zhang L, Zhou M, Lu L, Wu L, He N, Wang J, Li R, Guo Y. Zhen H, et al. Acta Biochim Biophys Sin (Shanghai). 2021 Jul 28;53(8):1098-1105. doi: 10.1093/abbs/gmab083. Acta Biochim Biophys Sin (Shanghai). 2021. PMID: 34169322 Free article.

4

Antiviral Properties of the LSD1 Inhibitor SP-2509.

Harancher MR, Packard JE, Cowan SP, DeLuca NA, Dembowski JA. Harancher MR, et al. J Virol. 2020 Sep 15;94(19):e00974-20. doi: 10.1128/JVI.00974-20. Print 2020 Sep 15. J Virol. 2020. PMID: 32699090 Free PMC article.

5

Small molecule inhibition of lysine-specific demethylase 1 (LSD1) and histone deacetylase (HDAC) alone and in combination in Ewing sarcoma cell lines.

Welch D, Kahen E, Fridley B, Brohl AS, Cubitt CL, Reed DR. Welch D, et al. PLoS One. 2019 Sep 24;14(9):e0222228. doi: 10.1371/journal.pone.0222228. eCollection 2019. PLoS One. 2019. PMID: 31550266 Free PMC article.

6

Suppression of LSD1 enhances the cytotoxic and apoptotic effects of regorafenib in hepatocellular carcinoma cells.

Wu LW, Zhou DM, Zhang ZY, Zhang JK, Zhu HJ, Lin NM, Zhang C. Wu LW, et al. Biochem Biophys Res Commun. 2019 May 14;512(4):852-858. doi: 10.1016/j.bbrc.2019.03.154. Epub 2019 Mar 28. Biochem Biophys Res Commun. 2019. PMID: 30929918

7

LSD1 activates a lethal prostate cancer gene network independently of its demethylase function.

Sehrawat A, Gao L, Wang Y, Bankhead A 3rd, McWeeney SK, King CJ, Schwartzman J, Urrutia J, Bisson WH, Coleman DJ, Joshi SK, Kim DH, Sampson DA, Weinmann S, Kallakury BVS, Berry DL, Haque R, Van Den Eeden SK, Sharma S, Bearss J, Beer TM, Thomas GV, Heiser LM, Alumkal JJ. Sehrawat A, et al. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188. doi: 10.1073/pnas.1719168115. Epub 2018 Mar 26. Proc Natl Acad Sci U S A. 2018. PMID: 29581250 Free PMC article.

8

LSD1 (KDM1A)-independent effects of the LSD1 inhibitor SP2509 in cancer cells.

Sonnemann J, Zimmermann M, Marx C, Ebert F, Becker S, Lauterjung ML, Beck JF. Sonnemann J, et al. Br J Haematol. 2018 Nov;183(3):494-497. doi: 10.1111/bjh.14983. Epub 2017 Dec 3. Br J Haematol. 2018. PMID: 29205263 Free article. No abstract available.

9

Novel combination of histone methylation modulators with therapeutic synergy against acute myeloid leukemia in vitro and in vivo.

Wen S, Wang J, Liu P, Li Y, Lu W, Hu Y, Liu J, He Z, Huang P. Wen S, et al. Cancer Lett. 2018 Jan 28;413:35-45. doi: 10.1016/j.canlet.2017.10.015. Epub 2017 Oct 22. Cancer Lett. 2018. PMID: 29069576

10

Stepwise assembly of functional C-terminal REST/NRSF transcriptional repressor complexes as a drug target.

Inui K, Zhao Z, Yuan J, Jayaprakash S, Le LTM, Drakulic S, Sander B, Golas MM. Inui K, et al. Protein Sci. 2017 May;26(5):997-1011. doi: 10.1002/pro.3142. Epub 2017 Mar 12. Protein Sci. 2017. PMID: 28218430 Free PMC article.

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