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37596270,37366237,36913846,36834782,36810913,36555360,36375313,36342242,36342213,36048859,36048820,35637059,35503763,35135451,35020602,35008640,34930349,34859954,34808137,34798200,34761330,34563947,34555415,34418237,34326272,34244426,34099492,34064363,34063748,34049949,34033941,34006821,33980612,33920782,33798773,33788127,33626354,33508418,33495648,33493298,33406006,33228044,33200801,33123902,33076974,32880392,32833332,32663610,32592403,32514740,32444674,32430324,32406303,32377295,32366892,32362197,32231045,32090372,32066940,32053935,32034646,32016997,32014016,31891641,31870119,31830357,31813919,31696568,31693468,31662509,31641080,31618076,31604003,31540695,31518555,31424367,31413360,31404503,31398252,31270333,31269729,31220391,31217429,31211863,31177541,31175100,31160548,31152240,31132310,31116877,31034517,31006590,31002870,30987073,30977277,30964980,30946605,30946604,30914305,30910357,30856534,30825555,30817767,30779249,30755236,30721324,30710396,30702927,30668972,30662889,30632675,30616891,30573360,30548818,30540820,30532069,30478173,30474622,30468782,30468479,30391731,30348767,30337562,30253109,30236513,30230919,30209366,30180452,30150719,30142540,30138163,30135087,30107094,30100905,30078213,30074837,30024790,30024290,29989581,29982462,29979626,29962100,29924486,29902536,29861059,29857061,29856969,29844217,29788824,29785900,29773885,29773845,29721631,29713651,29698445,29688769,29662023,29634397,29620138,29610348,29580989,29546654,29546577,29544475,29533739,29518344,29504069,29501754,29480490,29480488,29480485,29438738,29351415,29346025,29343420,29332906,29331024,29321306,29222348,29117108,29063699,29048631,29032594,29022062,28974562,28962892,28962017,28879656,28826664,28825205,28814760,28786140,28748494,28719670,28717968,28643197,28608291,28496098,28494020,28481450,28479394,28455001,28435970,28409163,28407446,28387458,28325600,28298333,28263818,28235712,28234358,28186975,28180061,28121062,28087254,28085510,28067669,28052040,28035400,28008135,27991529,27928820,27878239,27847321,27826658,27812978,27792760,27783307,27707786,27657826,27656952,27638620,27611085,27596506,27577855,27562249,27534994,27521792,27513082,27492924,27486508,27396599,27393564,27379837,27343360,27322180,27288451,27283242,27264993,27252492,27244599,27238967,27221022,27211901,27180888,27170207,27149559,27121619,27103584,27103440,27051236,26997622,26996194,26989860,26989010,26975895,26972986,26939902,26919657,26915321,26906634,26837005,26824904,26772531,26743435,26726793,26721419,26648451,26623971,26582176,26578698,26569535,26545901,26544976,26528831,26502054,26497305,26494902,26477890,26446934,26439636,26435693,26427488,26398569,26391395,26386875,26384382,26342801,26337027,26323019,26297684,26286955,26283791,26276035,26254015,26252753,26252187,26213325,26196303,26196300,26194188,26193886,26182383,26167077,26162096,26144885,26143491,26124049,26118534,26116041,26109067,26107620,26105159,26100042,26091000,26086963,26071020,26024098,26020972,26001600,25979627,25976932,25972015,25971373,25933205,25925859,25893566,25889494,25872765,25846006,25835326,25817233,25808811,25796381,25796089,25791529,25778901,25721362,25695398,25687571,25611433,25552597,25503106,25497570,25497117,25481457,25476093,25456115,25445464,25439672,25428125,25388945,25323047,25315694,25297543,25249576,25241895,25230326,25227129,25188319,25179079,25163923,25163918,25140811,25114075,25108154,25102273,25078608,25048039,25045295,25031357,25002509,24976178,24936055,24913514,24877601,24876288,24876095,24849329,24821673,24781943,24778186,24760559,24756886,24732361,24713487,24709998,24702155,24699405,24686086,24665903,24644240,24595038,24566685,24531544,24530802,24522207,24498249,24475189,24472542,24425763,24403860,24403081,24388462,24387947,24361598,24359245,24347059,24338821,24334768,24304883,24296672,24295634,24269733,24218086,24147777,24135141,24120945,24102298,24097562,24091934,24088893,24081524,24055274,24047401,24012549,24008375,24005536,23993965,23988673,23936035,23933835,23922739,23918774,23916727,23906767,23899558,23899325,23892475,23887097,23886299,23876340,23871790,23863407,23828211,23825223,23813470,23805277,23799098,23764851,23761105,23723070,23716168,23707791,23705032,23698161,23698110,23671658,23650203,23643731,23625915,23620811,23612073,23611224,23605481,23592276,23557706,23548904,23537779,23531513,23508272,23469683,23460021,23443926,23417865,23390161,23376257,23341495,23340307,23325788,23322781,23307774,23306156,23300996,23300870,23288166,23284795,23274900,23225245,23203966,23199370,23199202,23183898,23169238,23116772,23116613,23107762,23076989,23054058,23018889,22995402,22968644,22953992,22941773,22926241,22921370,22920997,22890317,22872592,22863860,22850868,22849866,22821946,22796442,22751115,22704782,22700432,22693207,22692279,22683340,22622802,22610379,22588166,22586267,22582096,22564403,22562518,22554803,22514710,22511782,22496244,22484146,22456184,22434076,22415077,22406377,22396201,22387548,22343549,22324445,22318952,22306847,22303451,22233421,22231556,22223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One-carbon metabolizing enzyme ALDH1L1 influences mitochondrial metabolism through 5-aminoimidazole-4-carboxamide ribonucleotide accumulation and serine depletion, contributing to tumor suppression.

Sasaki M, Yamamoto K, Ueda T, Irokawa H, Takeda K, Sekine R, Itoh F, Tanaka Y, Kuge S, Shibata N. Sasaki M, et al. Sci Rep. 2023 Aug 18;13(1):13486. doi: 10.1038/s41598-023-38142-5. Sci Rep. 2023. PMID: 37596270 Free PMC article.

Regulation of LRRK2 mRNA stability by ATIC and its substrate AICAR through ARE-mediated mRNA decay in Parkinson's disease.

Liu Q, Zhu D, Li N, Chen S, Hu L, Yu J, Xiong Y. Liu Q, et al. EMBO J. 2023 Aug 1;42(15):e113410. doi: 10.15252/embj.2022113410. Epub 2023 Jun 27. EMBO J. 2023. PMID: 37366237

AMPK activation by AICAR reduces diet induced fatty liver in C57BL/6 mice.

Krishnan U A, Viswanathan P, Venkataraman AC. Krishnan U A, et al. Tissue Cell. 2023 Jun;82:102054. doi: 10.1016/j.tice.2023.102054. Epub 2023 Mar 2. Tissue Cell. 2023. PMID: 36913846

AICAR Ameliorates Non-Alcoholic Fatty Liver Disease via Modulation of the HGF/NF-κB/SNARK Signaling Pathway and Restores Mitochondrial and Endoplasmic Reticular Impairments in High-Fat Diet-Fed Rats.

Zineldeen DH, Tahoon NM, Sarhan NI. Zineldeen DH, et al. Int J Mol Sci. 2023 Feb 8;24(4):3367. doi: 10.3390/ijms24043367. Int J Mol Sci. 2023. PMID: 36834782 Free PMC article.

An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1.

Aftab F, Rodriguez-Fuguet A, Silva L, Kobayashi IS, Sun J, Politi K, Levantini E, Zhang W, Kobayashi SS, Zhang WC. Aftab F, et al. Br J Cancer. 2023 May;128(9):1647-1664. doi: 10.1038/s41416-023-02196-z. Epub 2023 Feb 21. Br J Cancer. 2023. PMID: 36810913 Free PMC article.

AICAR Improves Outcomes of Metabolic Syndrome and Type 2 Diabetes Induced by High-Fat Diet in C57Bl/6 Male Mice.

Tukhovskaya EA, Shaykhutdinova ER, Pakhomova IA, Slashcheva GA, Goryacheva NA, Sadovnikova ES, Rasskazova EA, Kazakov VA, Dyachenko IA, Frolova AA, Brovkin AN, Kaluzhsky VE, Beburov MY, Murashev AN. Tukhovskaya EA, et al. Int J Mol Sci. 2022 Dec 11;23(24):15719. doi: 10.3390/ijms232415719. Int J Mol Sci. 2022. PMID: 36555360 Free PMC article.

AMPK activator AICAR in combination with anti-mouse IL10 mAb restores the functionality of intra-tumoral Tfh cells in the 4T1 mouse model.

Khamaru P, Chakraborty S, Bhattacharyya A. Khamaru P, et al. Cell Immunol. 2022 Dec;382:104639. doi: 10.1016/j.cellimm.2022.104639. Epub 2022 Nov 10. Cell Immunol. 2022. PMID: 36375313

AICAr to SAICAr ratio can serve as additional marker of AICAr use.

Sobolevsky T, Piper T, Ahrens B, Thevis M. Sobolevsky T, et al. Drug Test Anal. 2022 Nov;14(11-12):2017-2025. doi: 10.1002/dta.3399. Epub 2022 Nov 16. Drug Test Anal. 2022. PMID: 36342242

A plastid nucleoside kinase is involved in inosine salvage and control of purine nucleotide biosynthesis.

Chen X, Kim SH, Rhee S, Witte CP. Chen X, et al. Plant Cell. 2023 Jan 2;35(1):510-528. doi: 10.1093/plcell/koac320. Plant Cell. 2023. PMID: 36342213 Free PMC article.

Combinatorial treatment with exercise and AICAR potentiates the rescue of myotonic dystrophy type 1 mouse muscles in a sex-specific manner.

Misquitta NS, Ravel-Chapuis A, Jasmin BJ. Misquitta NS, et al. Hum Mol Genet. 2023 Jan 27;32(4):551-566. doi: 10.1093/hmg/ddac222. Hum Mol Genet. 2023. PMID: 36048859

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