The Structural Relationship between Iterative and Modular PKSs

Cell Chem Biol. 2016 May 19;23(5):540-542. doi: 10.1016/j.chembiol.2016.05.005.

Abstract

Recent work has characterized the architecture of a highly-reducing iterative polyketide synthase (PKS), the mycocerosic acid synthase (MAS) (Herbst et al., 2016). Beyond sharing a structural similarity with the mammalian fatty acid synthase (FAS), the authors argue that the MAS architecture is representative of some PKS modules.

Publication types

  • Comment

MeSH terms

  • Acyltransferases*
  • Animals
  • Polyketide Synthases*

Substances

  • Polyketide Synthases
  • Acyltransferases
  • mycocerosic acid synthase