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ABHD6 suppression promotes anti-inflammatory polarization of adipose tissue macrophages via 2-monoacylglycerol/PPAR signaling in obese mice.
Poursharifi P, Schmitt C, Chenier I, Leung YH, Oppong AK, Bai Y, Klein LL, Al-Mass A, Lussier R, Abu-Farha M, Abubaker J, Al-Mulla F, Peyot ML, Madiraju SRM, Prentki M. Poursharifi P, et al. Mol Metab. 2023 Dec;78:101822. doi: 10.1016/j.molmet.2023.101822. Epub 2023 Oct 12. Mol Metab. 2023. PMID: 37838014 Free PMC article.
The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors.
Marrs WR, Blankman JL, Horne EA, Thomazeau A, Lin YH, Coy J, Bodor AL, Muccioli GG, Hu SS, Woodruff G, Fung S, Lafourcade M, Alexander JP, Long JZ, Li W, Xu C, Möller T, Mackie K, Manzoni OJ, Cravatt BF, Stella N. Marrs WR, et al. Nat Neurosci. 2010 Aug;13(8):951-7. doi: 10.1038/nn.2601. Epub 2010 Jul 25. Nat Neurosci. 2010. PMID: 20657592 Free PMC article.