Identification of the major capsid protein gene of human herpesvirus 7

Virus Res. 1995 Jun;37(1):55-62. doi: 10.1016/0168-1702(95)00022-i.

Abstract

Two human herpesvirus 6 (HHV-6) open reading frames were identified with significant amino acid similarity to UL86 (major capsid protein, MCP) and UL85 of human cytomegalovirus (HCMV) in human herpesvirus 7 (HHV-7) genes. The predicted lengths of the complete HHV-7 MCP and the HCMV-UL85 open reading frames were 1344 and 293 amino acids with estimated molecular weights of approximately 153 and 33 kDa, respectively. Computer analysis showed that the amino acid of HHV-7 MCP was 61% identical to the MCP of HHV-6 variants A and B, 28% to HCMV. These results suggest that HHV-7 is more closely related to HHV-6 than to HCMV.

MeSH terms

  • Adult
  • Animals
  • Base Sequence
  • Capsid / genetics*
  • Cells, Cultured
  • Cytomegalovirus / classification
  • Cytomegalovirus / genetics
  • DNA Primers
  • Herpesviridae / genetics
  • Herpesviridae / metabolism
  • Herpesvirus 6, Human / classification
  • Herpesvirus 6, Human / genetics
  • Herpesvirus 7, Human / classification
  • Herpesvirus 7, Human / genetics*
  • Herpesvirus 7, Human / isolation & purification
  • Humans
  • Molecular Sequence Data
  • Open Reading Frames
  • Phylogeny
  • Sequence Homology, Nucleic Acid

Substances

  • DNA Primers

Associated data

  • GENBANK/D32005