Abstract
The genomic DNA sequence of herpes simplex virus type 2 (HSV-2) strain HG52 was determined as 154,746 bp with a G+C content of 70.4%. A total of 74 genes encoding distinct proteins was identified; three of these were each present in two copies, within major repeat elements of the genome. The HSV-2 gene set corresponds closely with that of HSV-1, and the HSV-2 sequence prompted several local revisions to the published HSV-1 sequence (D. J. McGeoch, M. A. Dalrymple, A. J. Davison, A. Dolan, M. C. Frame, D. McNab, L. J. Perry, J. E. Scott, and P. Taylor, J. Gen. Virol. 69:1531-1574, 1988). No compelling evidence for the existence of any additional protein-coding genes in HSV-2 was identified.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Capsid / genetics
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Capsid Proteins
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DNA Helicases / genetics
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DNA Primase
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DNA, Viral
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Genes, Viral
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Genome, Viral*
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Herpesvirus 1, Human / genetics
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Herpesvirus 2, Human / genetics*
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Humans
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Immediate-Early Proteins / genetics
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Molecular Sequence Data
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Sequence Analysis, DNA*
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Sequence Homology, Amino Acid
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Viral Fusion Proteins / genetics
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Viral Proteins / genetics
Substances
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Capsid Proteins
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DNA, Viral
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ICP47 protein, Herpes simplex virus
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Immediate-Early Proteins
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UL36 protein, Human herpesvirus 1
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VP13-14 protein, herpes simplex virus type 1
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VP5 protein, Herpes simplex virus type 1
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Viral Fusion Proteins
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Viral Proteins
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DNA Primase
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helicase-primase, Human herpesvirus 1
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DNA Helicases