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Asp-to-Asn substitution at the first position of the DxD TOPRIM motif of recombinant bacterial topoisomerase I is extremely lethal to E. coli.

Cheng B, Annamalai T, Sorokin E, Abrenica M, Aedo S, Tse-Dinh YC.

J Mol Biol. 2009 Jan 16;385(2):558-67. doi: 10.1016/j.jmb.2008.10.073. Epub 2008 Nov 5.


Inhibition of Mg2+ binding and DNA religation by bacterial topoisomerase I via introduction of an additional positive charge into the active site region.

Sorokin EP, Cheng B, Rathi S, Aedo SJ, Abrenica MV, Tse-Dinh YC.

Nucleic Acids Res. 2008 Aug;36(14):4788-96. doi: 10.1093/nar/gkn460. Epub 2008 Jul 24.


Bacterial cell killing mediated by topoisomerase I DNA cleavage activity.

Cheng B, Shukla S, Vasunilashorn S, Mukhopadhyay S, Tse-Dinh YC.

J Biol Chem. 2005 Nov 18;280(46):38489-95. Epub 2005 Sep 13.


The strictly conserved Arg-321 residue in the active site of Escherichia coli topoisomerase I plays a critical role in DNA rejoining.

Narula G, Annamalai T, Aedo S, Cheng B, Sorokin E, Wong A, Tse-Dinh YC.

J Biol Chem. 2011 May 27;286(21):18673-80. doi: 10.1074/jbc.M111.229450. Epub 2011 Apr 7.


Crystal structure of a covalent intermediate in DNA cleavage and rejoining by Escherichia coli DNA topoisomerase I.

Zhang Z, Cheng B, Tse-Dinh YC.

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6939-44. doi: 10.1073/pnas.1100300108. Epub 2011 Apr 11.


Antimicrobial Susceptibility and SOS-Dependent Increase in Mutation Frequency Are Impacted by Escherichia coli Topoisomerase I C-Terminal Point Mutation.

Yang J, Annamalai T, Cheng B, Banda S, Tyagi R, Tse-Dinh YC.

Antimicrob Agents Chemother. 2015 Oct;59(10):6195-202. doi: 10.1128/AAC.00855-15. Epub 2015 Jul 27.


Regulation of catalysis by the smallpox virus topoisomerase.

Hwang Y, Minkah N, Perry K, Van Duyne GD, Bushman FD.

J Biol Chem. 2006 Dec 8;281(49):38052-60. Epub 2006 Oct 10.


Bacterial topoisomerase I as a target for discovery of antibacterial compounds.

Tse-Dinh YC.

Nucleic Acids Res. 2009 Feb;37(3):731-7. doi: 10.1093/nar/gkn936. Epub 2008 Nov 28. Review.


Analysis of RuvABC and RecG involvement in the escherichia coli response to the covalent topoisomerase-DNA complex.

Sutherland JH, Tse-Dinh YC.

J Bacteriol. 2010 Sep;192(17):4445-51. doi: 10.1128/JB.00350-10. Epub 2010 Jul 2.


Importance of conserved acidic residues in mntH, the Nramp homolog of Escherichia coli.

Haemig HA, Brooker RJ.

J Membr Biol. 2004 Sep 15;201(2):97-107.


Deciphering the distinct role for the metal coordination motif in the catalytic activity of Mycobacterium smegmatis topoisomerase I.

Bhat AG, Leelaram MN, Hegde SM, Nagaraja V.

J Mol Biol. 2009 Nov 6;393(4):788-802. doi: 10.1016/j.jmb.2009.08.064. Epub 2009 Sep 3.


Residues of E. coli topoisomerase I conserved for interaction with a specific cytosine base to facilitate DNA cleavage.

Narula G, Tse-Dinh YC.

Nucleic Acids Res. 2012 Oct;40(18):9233-43. doi: 10.1093/nar/gks688. Epub 2012 Jul 24.


A Fluorescence-Based Assay for Identification of Bacterial Topoisomerase I Poisons.

Annamalai T, Cheng B, Keswani N, Tse-Dinh YC.

Methods Mol Biol. 2018;1703:259-268. doi: 10.1007/978-1-4939-7459-7_18.


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