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Identification of Sp1 as a Transcription Activator to Regulate Fibroblast Growth Factor 21 Gene Expression.

Chen S, Li H, Zhang J, Jiang S, Zhang M, Xu Y, Dong K, Yang Y, Fang Q, Jia W.

Biomed Res Int. 2017;2017:8402035. doi: 10.1155/2017/8402035. Epub 2017 Mar 29.


Negative regulation of DsbA-L gene expression by the transcription factor Sp1.

Fang Q, Yang W, Li H, Hu W, Chen L, Jiang S, Dong K, Song Q, Wang C, Chen S, Liu F, Jia W.

Diabetes. 2014 Dec;63(12):4165-71. doi: 10.2337/db14-0182. Epub 2014 Jul 14.


Hydrodynamic delivery of FGF21 gene alleviates obesity and fatty liver in mice fed a high-fat diet.

Gao M, Ma Y, Cui R, Liu D.

J Control Release. 2014 Jul 10;185:1-11. doi: 10.1016/j.jconrel.2014.03.047. Epub 2014 Apr 18.


Growth hormone stimulates transcription of the fibroblast growth factor 21 gene in the liver through the signal transducer and activator of transcription 5.

Yu J, Zhao L, Wang A, Eleswarapu S, Ge X, Chen D, Jiang H.

Endocrinology. 2012 Feb;153(2):750-8. doi: 10.1210/en.2011-1591. Epub 2011 Dec 13.


Naringenin prevents obesity, hepatic steatosis, and glucose intolerance in male mice independent of fibroblast growth factor 21.

Assini JM, Mulvihill EE, Burke AC, Sutherland BG, Telford DE, Chhoker SS, Sawyez CG, Drangova M, Adams AC, Kharitonenkov A, Pin CL, Huff MW.

Endocrinology. 2015 Jun;156(6):2087-102. doi: 10.1210/en.2014-2003. Epub 2015 Mar 16.


Increased fibroblast growth factor 21 expression in high-fat diet-sensitive non-human primates (Macaca mulatta).

Nygaard EB, Møller CL, Kievit P, Grove KL, Andersen B.

Int J Obes (Lond). 2014 Feb;38(2):183-91. doi: 10.1038/ijo.2013.79. Epub 2013 May 21.


Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice.

Morrice N, Mcilroy GD, Tammireddy SR, Reekie J, Shearer KD, Doherty MK, Delibegović M, Whitfield PD, Mody N.

Sci Rep. 2017 Mar 3;7:43782. doi: 10.1038/srep43782.


Nrf2 represses FGF21 during long-term high-fat diet-induced obesity in mice.

Chartoumpekis DV, Ziros PG, Psyrogiannis AI, Papavassiliou AG, Kyriazopoulou VE, Sykiotis GP, Habeos IG.

Diabetes. 2011 Oct;60(10):2465-73. doi: 10.2337/db11-0112. Epub 2011 Aug 18.


Involvement of Sp1 binding sequences in basal transcription of the rat fibroblast growth factor-2 gene in neonatal cardiomyocytes.

Tang W, Pan Q, Sun F, Ma J, Tang S, Le K, Wan Y, Chen Q, Liu P.

Life Sci. 2009 Mar 27;84(13-14):421-7. doi: 10.1016/j.lfs.2009.01.005. Epub 2009 Jan 24.


TRIB3 limits FGF21 induction during in vitro and in vivo nutrient deficiencies by inhibiting C/EBP-ATF response elements in the Fgf21 promoter.

Örd T, Örd D, Örd T.

Biochim Biophys Acta Gene Regul Mech. 2018 Mar;1861(3):271-281. doi: 10.1016/j.bbagrm.2018.01.014. Epub 2018 Jan 31.


Fibroblast growth factor (Fgf) 21 is a novel target gene of the aryl hydrocarbon receptor (AhR).

Cheng X, Vispute SG, Liu J, Cheng C, Kharitonenkov A, Klaassen CD.

Toxicol Appl Pharmacol. 2014 Jul 1;278(1):65-71. doi: 10.1016/j.taap.2014.04.013. Epub 2014 Apr 24.


Sp1 and AP2 enhance promoter activity of the mouse GM3-synthase gene.

Xia T, Zeng G, Gao L, Yu RK.

Gene. 2005 May 23;351:109-18.


Fibroblast growth factor 21 is regulated by the IRE1α-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis.

Jiang S, Yan C, Fang QC, Shao ML, Zhang YL, Liu Y, Deng YP, Shan B, Liu JQ, Li HT, Yang L, Zhou J, Dai Z, Liu Y, Jia WP.

J Biol Chem. 2014 Oct 24;289(43):29751-65. doi: 10.1074/jbc.M114.565960. Epub 2014 Aug 28.


Regulation of KLF5 involves the Sp1 transcription factor in human epithelial cells.

Chen C, Zhou Y, Zhou Z, Sun X, Otto KB, Uht RM, Dong JT.

Gene. 2004 Apr 14;330:133-42.


Lack of overt FGF21 resistance in two mouse models of obesity and insulin resistance.

Hale C, Chen MM, Stanislaus S, Chinookoswong N, Hager T, Wang M, Véniant MM, Xu J.

Endocrinology. 2012 Jan;153(1):69-80. doi: 10.1210/en.2010-1262. Epub 2011 Nov 8.


Overexpression of β-Klotho in Adipose Tissue Sensitizes Male Mice to Endogenous FGF21 and Provides Protection From Diet-Induced Obesity.

Samms RJ, Cheng CC, Kharitonenkov A, Gimeno RE, Adams AC.

Endocrinology. 2016 Apr;157(4):1467-80. doi: 10.1210/en.2015-1722. Epub 2016 Feb 22.


Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress.

Yang C, Lu W, Lin T, You P, Ye M, Huang Y, Jiang X, Wang C, Wang F, Lee MH, Yeung SC, Johnson RL, Wei C, Tsai RY, Frazier ML, McKeehan WL, Luo Y.

BMC Gastroenterol. 2013 Apr 17;13:67. doi: 10.1186/1471-230X-13-67.

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