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Adiponectin modulates oxidative stress-induced mitophagy and protects C2C12 myoblasts against apoptosis.

Ren Y, Li Y, Yan J, Ma M, Zhou D, Xue Z, Zhang Z, Liu H, Yang H, Jia L, Zhang L, Zhang Q, Mu S, Zhang R, Da Y.

Sci Rep. 2017 Jun 9;7(1):3209. doi: 10.1038/s41598-017-03319-2.


The cytoprotective effects of 7,8-dihydroxyflavone against oxidative stress are mediated by the upregulation of Nrf2-dependent HO-1 expression through the activation of the PI3K/Akt and ERK pathways in C2C12 myoblasts.

Kang JS, Choi IW, Han MH, Kim GY, Hong SH, Park C, Hwang HJ, Kim CM, Kim BW, Choi YH.

Int J Mol Med. 2015 Aug;36(2):501-10. doi: 10.3892/ijmm.2015.2256. Epub 2015 Jun 22.


Sargassum horneri methanol extract rescues C2C12 murine skeletal muscle cells from oxidative stress-induced cytotoxicity through Nrf2-mediated upregulation of heme oxygenase-1.

Kang JS, Choi IW, Han MH, Hong SH, Kim SO, Kim GY, Hwang HJ, Kim BW, Choi BT, Kim CM, Choi YH.

BMC Complement Altern Med. 2015 Feb 5;15:17. doi: 10.1186/s12906-015-0538-2.


The Cytoprotective Effect of Petalonia binghamiae Methanol Extract against Oxidative Stress in C2C12 Myoblasts: Mediation by Upregulation of Heme Oxygenase-1 and Nuclear Factor-Erythroid 2 Related Factor 2.

Kang JS, Choi IW, Han MH, Lee DS, Kim GY, Hwang HJ, Kim BW, Kim CM, Yoo YH, Choi YH.

Mar Drugs. 2015 Apr 29;13(5):2666-79. doi: 10.3390/md13052666.


Morin exerts cytoprotective effects against oxidative stress in C2C12 myoblasts via the upregulation of Nrf2-dependent HO-1 expression and the activation of the ERK pathway.

Lee MH, Han MH, Lee DS, Park C, Hong SH, Kim GY, Hong SH, Song KS, Choi IW, Cha HJ, Choi YH.

Int J Mol Med. 2017 Feb;39(2):399-406. doi: 10.3892/ijmm.2016.2837. Epub 2016 Dec 23.


Nrf2-mediated HO-1 induction contributes to antioxidant capacity of a Schisandrae Fructus ethanol extract in C2C12 myoblasts.

Kang JS, Han MH, Kim GY, Kim CM, Kim BW, Hwang HJ, Hyun Y.

Nutrients. 2014 Dec;6(12):5667-78.


An exploration of the antioxidant effects of garlic saponins in mouse-derived C2C12 myoblasts.

Kang JS, Kim SO, Kim GY, Hwang HJ, Kim BW, Chang YC, Kim WJ, Kim CM, Yoo YH, Choi YH.

Int J Mol Med. 2016 Jan;37(1):149-56. doi: 10.3892/ijmm.2015.2398. Epub 2015 Oct 30.


Cytoprotective effect of chlorogenic acid against hydrogen peroxide-induced oxidative stress in MC3T3-E1 cells through PI3K/Akt-mediated Nrf2/HO-1 signaling pathway.

Han D, Chen W, Gu X, Shan R, Zou J, Liu G, Shahid M, Gao J, Han B.

Oncotarget. 2017 Feb 28;8(9):14680-14692. doi: 10.18632/oncotarget.14747.


Cytoprotective effects of esculetin against oxidative stress are associated with the upregulation of Nrf2-mediated NQO1 expression via the activation of the ERK pathway.

Han MH, Park C, Lee DS, Hong SH, Choi IW, Kim GY, Choi SH, Shim JH, Chae JI, Yoo YH, Choi YH.

Int J Mol Med. 2017 Feb;39(2):380-386. doi: 10.3892/ijmm.2016.2834. Epub 2016 Dec 16.


Activation of cannabinoid type 2 receptor protects skeletal muscle from ischemia-reperfusion injury partly via Nrf2 signaling.

Zhang M, Zhang M, Wang L, Yu T, Jiang S, Jiang P, Sun Y, Pi J, Zhao R, Guan D.

Life Sci. 2019 Aug 1;230:55-67. doi: 10.1016/j.lfs.2019.05.056. Epub 2019 May 22.


Parthenolide regulates oxidative stress-induced mitophagy and suppresses apoptosis through p53 signaling pathway in C2C12 myoblasts.

Ren Y, Li Y, Lv J, Guo X, Zhang J, Zhou D, Zhang Z, Xue Z, Yang G, Xi Q, Liu H, Liu Z, Zhang L, Zhang Q, Yao Z, Zhang R, Da Y.

J Cell Biochem. 2019 Sep;120(9):15695-15708. doi: 10.1002/jcb.28839. Epub 2019 May 29.


Dietary resveratrol confers apoptotic resistance to oxidative stress in myoblasts.

Haramizu S, Asano S, Butler DC, Stanton DA, Hajira A, Mohamed JS, Alway SE.

J Nutr Biochem. 2017 Dec;50:103-115. doi: 10.1016/j.jnutbio.2017.08.008. Epub 2017 Aug 24.


Schisandrin A prevents oxidative stress-induced DNA damage and apoptosis by attenuating ROS generation in C2C12 cells.

Choi YH.

Biomed Pharmacother. 2018 Oct;106:902-909. doi: 10.1016/j.biopha.2018.07.035. Epub 2018 Jul 12.


Cytoprotective effects of diosmetin against hydrogen peroxide-induced L02 cell oxidative damage via activation of the Nrf2-ARE signaling pathway.

Wang C, Liao Y, Wang S, Wang D, Wu N, Xu Q, Jiang W, Qiu M, Liu C.

Mol Med Rep. 2018 May;17(5):7331-7338. doi: 10.3892/mmr.2018.8750. Epub 2018 Mar 15.


Homoeriodictyol protects human endothelial cells against oxidative insults through activation of Nrf2 and inhibition of mitochondrial dysfunction.

Shen T, Li HZ, Li AL, Li YR, Wang XN, Ren DM.

Vascul Pharmacol. 2018 Oct;109:72-82. doi: 10.1016/j.vph.2018.06.007. Epub 2018 Jun 11.


Astaxanthin protects ARPE-19 cells from oxidative stress via upregulation of Nrf2-regulated phase II enzymes through activation of PI3K/Akt.

Li Z, Dong X, Liu H, Chen X, Shi H, Fan Y, Hou D, Zhang X.

Mol Vis. 2013 Jul 25;19:1656-66. Print 2013.

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