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Items: 1 to 20 of 99

1.

Toxin-mediated ribosome stalling reprograms the Mycobacterium tuberculosis proteome.

Barth VC, Zeng JM, Vvedenskaya IO, Ouyang M, Husson RN, Woychik NA.

Nat Commun. 2019 Jul 10;10(1):3035. doi: 10.1038/s41467-019-10869-8.

2.

tRNA is a new target for cleavage by a MazF toxin.

Schifano JM, Cruz JW, Vvedenskaya IO, Edifor R, Ouyang M, Husson RN, Nickels BE, Woychik NA.

Nucleic Acids Res. 2016 Feb 18;44(3):1256-70. doi: 10.1093/nar/gkv1370. Epub 2016 Jan 5.

3.

Structure of the MazF-mt9 toxin, a tRNA-specific endonuclease from Mycobacterium tuberculosis.

Chen R, Tu J, Liu Z, Meng F, Ma P, Ding Z, Yang C, Chen L, Deng X, Xie W.

Biochem Biophys Res Commun. 2017 May 6;486(3):804-810. doi: 10.1016/j.bbrc.2017.03.132. Epub 2017 Mar 25.

PMID:
28351618
4.

Mycobacterial toxin MazF-mt6 inhibits translation through cleavage of 23S rRNA at the ribosomal A site.

Schifano JM, Edifor R, Sharp JD, Ouyang M, Konkimalla A, Husson RN, Woychik NA.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8501-6. doi: 10.1073/pnas.1222031110. Epub 2013 May 6.

5.

Modified nucleoside dependent Watson-Crick and wobble codon binding by tRNALysUUU species.

Yarian C, Marszalek M, Sochacka E, Malkiewicz A, Guenther R, Miskiewicz A, Agris PF.

Biochemistry. 2000 Nov 7;39(44):13390-5.

PMID:
11063576
6.

Preferences of AAA/AAG codon recognition by modified nucleosides, τm5s2U34 and t6A37 present in tRNALys.

Sonawane KD, Kamble AS, Fandilolu PM.

J Biomol Struct Dyn. 2018 Dec;36(16):4182-4196. doi: 10.1080/07391102.2017.1417911. Epub 2017 Dec 27.

PMID:
29243556
7.

Thio-Modification of tRNA at the Wobble Position as Regulator of the Kinetics of Decoding and Translocation on the Ribosome.

Ranjan N, Rodnina MV.

J Am Chem Soc. 2017 Apr 26;139(16):5857-5864. doi: 10.1021/jacs.7b00727. Epub 2017 Apr 13.

PMID:
28368583
8.

The role of modifications in codon discrimination by tRNA(Lys)UUU.

Murphy FV 4th, Ramakrishnan V, Malkiewicz A, Agris PF.

Nat Struct Mol Biol. 2004 Dec;11(12):1186-91. Epub 2004 Nov 21.

PMID:
15558052
9.

Highly specific and efficient cleavage of squid tRNA(Lys) catalyzed by magnesium ions.

Matsuo M, Yokogawa T, Nishikawa K, Watanabe K, Okada N.

J Biol Chem. 1995 Apr 28;270(17):10097-104.

10.

Human tRNA(Lys3)(UUU) is pre-structured by natural modifications for cognate and wobble codon binding through keto-enol tautomerism.

Vendeix FA, Murphy FV 4th, Cantara WA, Leszczyńska G, Gustilo EM, Sproat B, Malkiewicz A, Agris PF.

J Mol Biol. 2012 Mar 2;416(4):467-85. doi: 10.1016/j.jmb.2011.12.048. Epub 2011 Dec 29.

12.

Independent suppression of ribosomal +1 frameshifts by different tRNA anticodon loop modifications.

Klassen R, Bruch A, Schaffrath R.

RNA Biol. 2017 Sep 2;14(9):1252-1259. doi: 10.1080/15476286.2016.1267098. Epub 2016 Dec 12.

13.

Cloaked dagger: tRNA slicing by an unlikely culprit.

Schifano JM, Woychik NA.

RNA Biol. 2017 Jan 2;14(1):15-19. doi: 10.1080/15476286.2016.1255396. Epub 2016 Nov 14. Review.

14.

Protein synthesis factors (RF1, RF2, RF3, RRF, and tmRNA) and peptidyl-tRNA hydrolase rescue stalled ribosomes at sense codons.

Vivanco-Domínguez S, Bueno-Martínez J, León-Avila G, Iwakura N, Kaji A, Kaji H, Guarneros G.

J Mol Biol. 2012 Apr 13;417(5):425-39. doi: 10.1016/j.jmb.2012.02.008. Epub 2012 Feb 9.

PMID:
22326347
15.

Growth-regulating Mycobacterium tuberculosis VapC-mt4 toxin is an isoacceptor-specific tRNase.

Cruz JW, Sharp JD, Hoffer ED, Maehigashi T, Vvedenskaya IO, Konkimalla A, Husson RN, Nickels BE, Dunham CM, Woychik NA.

Nat Commun. 2015 Jul 9;6:7480. doi: 10.1038/ncomms8480.

16.

Accurate target identification for Mycobacterium tuberculosis endoribonuclease toxins requires expression in their native host.

Cintrón M, Zeng JM, Barth VC, Cruz JW, Husson RN, Woychik NA.

Sci Rep. 2019 Apr 11;9(1):5949. doi: 10.1038/s41598-019-41548-9.

17.

The UGG Isoacceptor of tRNAPro Is Naturally Prone to Frameshifts.

Gamper HB, Masuda I, Frenkel-Morgenstern M, Hou YM.

Int J Mol Sci. 2015 Jul 1;16(7):14866-83. doi: 10.3390/ijms160714866.

18.

23S rRNA as an a-Maz-ing new bacterial toxin target.

Schifano JM, Woychik NA.

RNA Biol. 2014;11(2):101-5. doi: 10.4161/rna.27949. Epub 2014 Feb 7.

19.

Codon-Specific Translation by m1G37 Methylation of tRNA.

Hou YM, Masuda I, Gamper H.

Front Genet. 2019 Jan 10;9:713. doi: 10.3389/fgene.2018.00713. eCollection 2018.

20.

Functional anticodon architecture of human tRNALys3 includes disruption of intraloop hydrogen bonding by the naturally occurring amino acid modification, t6A.

Stuart JW, Gdaniec Z, Guenther R, Marszalek M, Sochacka E, Malkiewicz A, Agris PF.

Biochemistry. 2000 Nov 7;39(44):13396-404.

PMID:
11063577

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