Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 1
2006 4
2007 2
2008 3
2009 4
2010 5
2011 7
2012 7
2013 4
2014 6
2015 7
2016 3
2017 8
2018 9
2019 10
2020 14
2021 8
2022 18
2023 15
2024 2

Text availability

Article attribute

Article type

Publication date

Search Results

114 results

Results by year

Filters applied: . Clear all
Page 1
The Clinical Spectrum of PTEN Mutations.
Yehia L, Keel E, Eng C. Yehia L, et al. Annu Rev Med. 2020 Jan 27;71:103-116. doi: 10.1146/annurev-med-052218-125823. Epub 2019 Aug 21. Annu Rev Med. 2020. PMID: 31433956 Review.
With time, it became evident that PTEN mutations can result in a broad phenotypic spectrum, causing seemingly disparate disorders from cancer to autism. Hence, the umbrella term of PTEN hamartoma tumor syndrome (PHTS) was coined. Timely diagnosis and u …
With time, it became evident that PTEN mutations can result in a broad phenotypic spectrum, causing seemingly disparate disorders from cance …
Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria.
Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E. Pilarski R, et al. J Natl Cancer Inst. 2013 Nov 6;105(21):1607-16. doi: 10.1093/jnci/djt277. Epub 2013 Oct 17. J Natl Cancer Inst. 2013. PMID: 24136893 Review.
BACKGROUND: PTEN hamartoma tumor syndrome (PHTS) refers to a spectrum of disorders caused by mutations in the phosphatase and tensin homolog (PTEN) gene. ...
BACKGROUND: PTEN hamartoma tumor syndrome (PHTS) refers to a spectrum of disorders caused by mutations in the ph …
WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition.
Lee YR, Yehia L, Kishikawa T, Ni Y, Leach B, Zhang J, Panch N, Liu J, Wei W, Eng C, Pandolfi PP. Lee YR, et al. N Engl J Med. 2020 May 28;382(22):2103-2116. doi: 10.1056/NEJMoa1914919. N Engl J Med. 2020. PMID: 32459922 Free PMC article.
BACKGROUND: Patients with PTEN hamartoma tumor syndrome (PHTS) have germline mutations in the tumor-suppressor gene encoding phosphatase and tensin homologue (PTEN). ...
BACKGROUND: Patients with PTEN hamartoma tumor syndrome (PHTS) have germline mutations in the tumor-suppressor g …
PTEN hamartoma tumor syndrome.
Mester J, Charis E. Mester J, et al. Handb Clin Neurol. 2015;132:129-37. doi: 10.1016/B978-0-444-62702-5.00009-3. Handb Clin Neurol. 2015. PMID: 26564076 Review.
PTEN hamartoma tumor syndrome (PHTS) is the molecular diagnostic term describing patients with Cowden syndrome, Bannayan-Riley-Ruvalcaba syndrome, and other clinical presentations with germline mutation of the PTEN tumor suppressor gene. ...
PTEN hamartoma tumor syndrome (PHTS) is the molecular diagnostic term describing patients with Cowden syndrome,
Gastrointestinal manifestations in PTEN hamartoma tumor syndrome.
D'Ermo G, Genuardi M. D'Ermo G, et al. Best Pract Res Clin Gastroenterol. 2022 Jun-Aug;58-59:101792. doi: 10.1016/j.bpg.2022.101792. Epub 2022 Mar 17. Best Pract Res Clin Gastroenterol. 2022. PMID: 35988965 Review.
The PTEN hamartoma tumor syndrome (PHTS) is a heterogeneous set of multisystem disorders caused by germline pathogenic variants in the PTEN tumor suppressor gene. ...
The PTEN hamartoma tumor syndrome (PHTS) is a heterogeneous set of multisystem disorders caused by germline path …
A clinical scoring system for selection of patients for PTEN mutation testing is proposed on the basis of a prospective study of 3042 probands.
Tan MH, Mester J, Peterson C, Yang Y, Chen JL, Rybicki LA, Milas K, Pederson H, Remzi B, Orloff MS, Eng C. Tan MH, et al. Am J Hum Genet. 2011 Jan 7;88(1):42-56. doi: 10.1016/j.ajhg.2010.11.013. Epub 2010 Dec 30. Am J Hum Genet. 2011. PMID: 21194675 Free PMC article.
Cowden syndrome (CS) and Bannayan-Riley-Ruvalcaba syndrome are allelic, defined by germline PTEN mutations, and collectively referred to as PTEN hamartoma tumor syndrome. To date, there are no existing criteria based on large prospective patient cohort …
Cowden syndrome (CS) and Bannayan-Riley-Ruvalcaba syndrome are allelic, defined by germline PTEN mutations, and collectively referred to as …
PTEN in Hereditary and Sporadic Cancer.
Ngeow J, Eng C. Ngeow J, et al. Cold Spring Harb Perspect Med. 2020 Apr 1;10(4):a036087. doi: 10.1101/cshperspect.a036087. Cold Spring Harb Perspect Med. 2020. PMID: 31570378 Free PMC article. Review.
Germline pathogenic phosphatase and tensin homolog (PTEN) mutations cause PTEN hamartoma tumor syndrome (PHTS), characterized by various benign and malignant tumors of the thyroid, breast, endometrium, and other organs. ...
Germline pathogenic phosphatase and tensin homolog (PTEN) mutations cause PTEN hamartoma tumor syndrome (PHTS), …
PTEN Hamartoma tumor syndrome in childhood: A review of the clinical literature.
Macken WL, Tischkowitz M, Lachlan KL. Macken WL, et al. Am J Med Genet C Semin Med Genet. 2019 Dec;181(4):591-610. doi: 10.1002/ajmg.c.31743. Epub 2019 Oct 14. Am J Med Genet C Semin Med Genet. 2019. PMID: 31609537 Review.
PTEN hamartoma tumor syndrome (PHTS) is a highly variable autosomal dominant condition associated with intellectual disability, overgrowth, and tumor predisposition phenotypes, which often overlap. ...
PTEN hamartoma tumor syndrome (PHTS) is a highly variable autosomal dominant condition associated with intellect
Hamartomatous polyposis syndromes.
Zbuk KM, Eng C. Zbuk KM, et al. Nat Clin Pract Gastroenterol Hepatol. 2007 Sep;4(9):492-502. doi: 10.1038/ncpgasthep0902. Nat Clin Pract Gastroenterol Hepatol. 2007. PMID: 17768394 Review.
These syndromes include juvenile polyposis syndrome, Peutz-Jeghers syndrome and the PTEN hamartoma tumor syndrome. The frequency and location of the polyps vary considerably among syndromes, as does the affected patient's predisposition to the developm …
These syndromes include juvenile polyposis syndrome, Peutz-Jeghers syndrome and the PTEN hamartoma tumor syndrome
114 results