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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 4
2003 20
2004 43
2005 58
2006 69
2007 81
2008 85
2009 93
2010 129
2011 124
2012 150
2013 187
2014 180
2015 207
2016 183
2017 192
2018 158
2019 147
2020 104
2021 101
2022 55
2023 56
2024 26

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2,211 results

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Page 1
The guideline of the design and validation of MiRNA mimics.
Wang Z. Wang Z. Methods Mol Biol. 2011;676:211-23. doi: 10.1007/978-1-60761-863-8_15. Methods Mol Biol. 2011. PMID: 20931400
Such an RNA fragment is designed to have its 5'-end bearing a partially complementary motif to the selected sequence in the 3'UTR unique to the target gene. Once introduced into cells, this RNA fragment, mimicking an endogenous miRNA, can bind specifically to its target …
Such an RNA fragment is designed to have its 5'-end bearing a partially complementary motif to the selected sequence in the 3'UTR unique to …
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials.
Lin A, Giuliano CJ, Palladino A, John KM, Abramowicz C, Yuan ML, Sausville EL, Lukow DA, Liu L, Chait AR, Galluzzo ZC, Tucker C, Sheltzer JM. Lin A, et al. Sci Transl Med. 2019 Sep 11;11(509):eaaw8412. doi: 10.1126/scitranslmed.aaw8412. Sci Transl Med. 2019. PMID: 31511426 Free PMC article.
Using CRISPR-Cas9 mutagenesis, we investigated a set of cancer drugs and drug targets in various stages of clinical testing. We show that-contrary to previous reports obtained predominantly with RNA interference and small-molecule inhibitors-the proteins oste …
Using CRISPR-Cas9 mutagenesis, we investigated a set of cancer drugs and drug targets in various stages of clinical testing. We show …
A phase I/II study of ARO-HSD, an RNA interference therapeutic, for the treatment of non-alcoholic steatohepatitis.
Mak LY, Gane E, Schwabe C, Yoon KT, Heo J, Scott R, Lee JH, Lee JI, Kweon YO, Weltman M, Harrison SA, Neuschwander-Tetri BA, Cusi K, Loomba R, Given BD, Christianson DR, Garcia-Medel E, Yi M, Hamilton J, Yuen MF. Mak LY, et al. J Hepatol. 2023 Apr;78(4):684-692. doi: 10.1016/j.jhep.2022.11.025. Epub 2022 Dec 10. J Hepatol. 2023. PMID: 36513186 Clinical Trial.
HSD17beta13 inhibition represents a potential approach to treat liver diseases, such as non-alcoholic steatohepatitis (NASH). ARO-HSD is an RNA interference (RNAi) therapeutic designed to selectively reduce expression of HSD17beta13 mRNA in hepatocytes. ...The reduc …
HSD17beta13 inhibition represents a potential approach to treat liver diseases, such as non-alcoholic steatohepatitis (NASH). ARO-HSD is an …
RNAi in Plasmodium.
Mueller AK, Hammerschmidt-Kamper C, Kaiser A. Mueller AK, et al. Curr Pharm Des. 2014;20(2):278-83. doi: 10.2174/13816128113199990027. Curr Pharm Des. 2014. PMID: 23701540 Review.
RNA interference (RNAi) has quickly proven to be an immensely useful tool for studying gene function and validation of potential drug targets in almost all organisms that possess the required set of proteins of the interference pathway. ...
RNA interference (RNAi) has quickly proven to be an immensely useful tool for studying gene function and validation of …
A Pipeline for Drug Target Identification and Validation.
Manchado E, Huang CH, Tasdemir N, Tschaharganeh DF, Wilkinson JE, Lowe SW. Manchado E, et al. Cold Spring Harb Symp Quant Biol. 2016;81:257-267. doi: 10.1101/sqb.2016.81.031096. Epub 2017 Jan 5. Cold Spring Harb Symp Quant Biol. 2016. PMID: 28057848 Free PMC article. Review.
Still, as inhibition of gene function can have diverse effects on both tumor and normal tissues, information on the potency of target inhibition on tumor growth as well as the toxic side effects of target inhibition are also needed. Here, we discuss our RNA …
Still, as inhibition of gene function can have diverse effects on both tumor and normal tissues, information on the potency of target …
RNA interference: Applications and advances in insect toxicology and insect pest management.
Kim YH, Soumaila Issa M, Cooper AM, Zhu KY. Kim YH, et al. Pestic Biochem Physiol. 2015 May;120:109-17. doi: 10.1016/j.pestbp.2015.01.002. Epub 2015 Jan 9. Pestic Biochem Physiol. 2015. PMID: 25987228 Review.
Since its discovery, RNA interference (RNAi) has revolutionized functional genomic studies due to its sequence-specific nature of post-transcriptional gene silencing. In this paper, we provide a comprehensive review of the recent literature and summarize the current …
Since its discovery, RNA interference (RNAi) has revolutionized functional genomic studies due to its sequence-specific nature …
RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes.
Subramanian M, McIninch J, Zlatev I, Schlegel MK, Kaittanis C, Nguyen T, Agarwal S, Racie T, Alvarado MA, Wassarman K, Collins TS, Chickering T, Brown CR, Schmidt K, Castoreno AB, Shulga-Morskaya S, Stamenova E, Buckowing K, Berman D, Barry JD, Bisbe A, Maier MA, Fitzgerald K, Jadhav V. Subramanian M, et al. Nat Commun. 2023 Apr 8;14(1):1970. doi: 10.1038/s41467-023-37774-5. Nat Commun. 2023. PMID: 37031257 Free PMC article.
Adeno-associated virus (AAV)-based gene therapy could be facilitated by the development of molecular switches to control the magnitude and timing of expression of therapeutic transgenes. RNA interference (RNAi)-based approaches hold unique potential as a clinically …
Adeno-associated virus (AAV)-based gene therapy could be facilitated by the development of molecular switches to control the magnitude and t …
Development of RNA interference-based therapeutics and application of multi-target small interfering RNAs.
Li T, Wu M, Zhu YY, Chen J, Chen L. Li T, et al. Nucleic Acid Ther. 2014 Aug;24(4):302-12. doi: 10.1089/nat.2014.0480. Epub 2014 May 5. Nucleic Acid Ther. 2014. PMID: 24796432 Review.
RNA interference (RNAi) has been proven in recent years to be a newly advanced and powerful tool for development of therapeutic agents toward various unmet medical needs such as cancer, in particular, a great attention has been paid to the development of antineoplas …
RNA interference (RNAi) has been proven in recent years to be a newly advanced and powerful tool for development of therapeuti …
MicroRNA Expression Profiling, Target Identification, and Validation in Chondrocytes.
Chiba T, Kurimoto R, Matsushima T, Ito Y, Nakamichi R, Lotz M, Asahara H. Chiba T, et al. Methods Mol Biol. 2021;2245:151-166. doi: 10.1007/978-1-0716-1119-7_11. Methods Mol Biol. 2021. PMID: 33315201 Free PMC article.
MicroRNAs (miRNAs) are a class of noncoding small RNAs, which play a critical role in various biological processes including musculoskeletal formation and arthritis pathogenesis via regulating target gene expressions, raising the potentially substantial effects on gene exp …
MicroRNAs (miRNAs) are a class of noncoding small RNAs, which play a critical role in various biological processes including musculoskeletal …
Target identification and mechanism of action in chemical biology and drug discovery.
Schenone M, Dančík V, Wagner BK, Clemons PA. Schenone M, et al. Nat Chem Biol. 2013 Apr;9(4):232-40. doi: 10.1038/nchembio.1199. Nat Chem Biol. 2013. PMID: 23508189 Free PMC article. Review.
Such studies allow small-molecule action to be tested in a more disease-relevant setting at the outset, but they require follow-up studies to determine the precise protein target or targets responsible for the observed phenotype. Target identification can be …
Such studies allow small-molecule action to be tested in a more disease-relevant setting at the outset, but they require follow-up studies t …
2,211 results