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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1985 1
1997 1
2001 2
2002 4
2003 10
2004 47
2005 46
2006 51
2007 39
2008 46
2009 43
2010 44
2011 50
2012 46
2013 51
2014 36
2015 40
2016 47
2017 35
2018 37
2019 29
2020 46
2021 56
2022 44
2023 44
2024 7

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822 results

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Page 1
Non-coding RNAs: Classification, Biology and Functioning.
Hombach S, Kretz M. Hombach S, et al. Adv Exp Med Biol. 2016;937:3-17. doi: 10.1007/978-3-319-42059-2_1. Adv Exp Med Biol. 2016. PMID: 27573892 Review.
A rapidly growing number of exceptions to this rule have been reported over the past decades: they include long known classes of RNAs involved in translation such as transfer RNAs and ribosomal RNAs, small nuclear RNAs involved in splicing events, and small nucleolar RNAs mainly …
A rapidly growing number of exceptions to this rule have been reported over the past decades: they include long known classes of RNAs involv …
RNA Interference: Story and Mechanisms.
Sioud M. Sioud M. Methods Mol Biol. 2021;2282:1-15. doi: 10.1007/978-1-0716-1298-9_1. Methods Mol Biol. 2021. PMID: 33928566 Review.
All endogenous RNA interference pathways share a conserved effector complex, which contains at least an argonaute protein and a short single-stranded RNA. Such argonaute-RNA complexes can repress the transcription of genes, target mRNA for site-specifi …
All endogenous RNA interference pathways share a conserved effector complex, which contains at least an argonaute protein and a sh …
siRNA vs. shRNA: similarities and differences.
Rao DD, Vorhies JS, Senzer N, Nemunaitis J. Rao DD, et al. Adv Drug Deliv Rev. 2009 Jul 25;61(9):746-59. doi: 10.1016/j.addr.2009.04.004. Epub 2009 Apr 20. Adv Drug Deliv Rev. 2009. PMID: 19389436 Review.
RNA interference (RNAi) is a natural process through which expression of a targeted gene can be knocked down with high specificity and selectivity. Using available technology and bioinformatics investigators will soon be able to identify relevant bio molecular tumor networ …
RNA interference (RNAi) is a natural process through which expression of a targeted gene can be knocked down with high specificity an …
Small interfering RNA: Discovery, pharmacology and clinical development-An introductory review.
Ranasinghe P, Addison ML, Dear JW, Webb DJ. Ranasinghe P, et al. Br J Pharmacol. 2023 Nov;180(21):2697-2720. doi: 10.1111/bph.15972. Epub 2022 Nov 13. Br J Pharmacol. 2023. PMID: 36250252 Review.
Post-transcriptional gene silencing targets and degrades mRNA transcripts, silencing the expression of specific genes. RNA interference technology, using synthetic structurally well-defined short double-stranded RNA (small interfering RNA [siRNA …
Post-transcriptional gene silencing targets and degrades mRNA transcripts, silencing the expression of specific genes. RNA interferen …
Nucleic acid delivery for therapeutic applications.
Gupta A, Andresen JL, Manan RS, Langer R. Gupta A, et al. Adv Drug Deliv Rev. 2021 Nov;178:113834. doi: 10.1016/j.addr.2021.113834. Epub 2021 Sep 4. Adv Drug Deliv Rev. 2021. PMID: 34492233 Review.
Recent medical advances have exploited the ability to address a given disease at the underlying level of transcription and translation. These treatment paradigms utilize nucleic acids - including short interfering RNA (siRNA), microRNA (miRNA), antisense olig …
Recent medical advances have exploited the ability to address a given disease at the underlying level of transcription and translation. Thes …
RNAi mechanisms in Caenorhabditis elegans.
Grishok A. Grishok A. FEBS Lett. 2005 Oct 31;579(26):5932-9. doi: 10.1016/j.febslet.2005.08.001. Epub 2005 Aug 9. FEBS Lett. 2005. PMID: 16162338 Free article. Review.
RNA interference (RNAi) is a form of gene silencing induced by double stranded RNA (dsRNA) that is processed into short interfering RNAs (siRNAs). ...
RNA interference (RNAi) is a form of gene silencing induced by double stranded RNA (dsRNA) that is processed into short …
RNA interference: biology, mechanism, and applications.
Agrawal N, Dasaradhi PV, Mohmmed A, Malhotra P, Bhatnagar RK, Mukherjee SK. Agrawal N, et al. Microbiol Mol Biol Rev. 2003 Dec;67(4):657-85. doi: 10.1128/MMBR.67.4.657-685.2003. Microbiol Mol Biol Rev. 2003. PMID: 14665679 Free PMC article. Review.
The silencing of a gene is a consequence of degradation of RNA into short RNAs that activate ribonucleases to target homologous mRNA. ...Several key components such as Dicer, RNA-dependent RNA polymerase, helicases, and dsRNA endonucleases have been id …
The silencing of a gene is a consequence of degradation of RNA into short RNAs that activate ribonucleases to target homologou …
Safety of antisense oligonucleotide and siRNA-based therapeutics.
Chi X, Gatti P, Papoian T. Chi X, et al. Drug Discov Today. 2017 May;22(5):823-833. doi: 10.1016/j.drudis.2017.01.013. Epub 2017 Jan 31. Drug Discov Today. 2017. PMID: 28159625 Review.
Two of the more promising platforms are the antisense oligonucleotides (ASOs) and short interfering RNAs (siRNAs), both of which are often directed against similar targets. ...
Two of the more promising platforms are the antisense oligonucleotides (ASOs) and short interfering RNAs (siRNAs), both of whi …
Origins and Mechanisms of miRNAs and siRNAs.
Carthew RW, Sontheimer EJ. Carthew RW, et al. Cell. 2009 Feb 20;136(4):642-55. doi: 10.1016/j.cell.2009.01.035. Cell. 2009. PMID: 19239886 Free PMC article. Review.
Over the last decade, approximately 20-30 nucleotide RNA molecules have emerged as critical regulators in the expression and function of eukaryotic genomes. Two primary categories of these small RNAs--short interfering RNAs (siRNAs) and microRNAs (miRNAs)--ac …
Over the last decade, approximately 20-30 nucleotide RNA molecules have emerged as critical regulators in the expression and function …
siRNA, miRNA, and shRNA: in vivo applications.
Pushparaj PN, Aarthi JJ, Manikandan J, Kumar SD. Pushparaj PN, et al. J Dent Res. 2008 Nov;87(11):992-1003. doi: 10.1177/154405910808701109. J Dent Res. 2008. PMID: 18946005 Review.
RNA interference (RNAi), an accurate and potent gene-silencing method, was first experimentally documented in 1998 in Caenorhabditis elegans by Fire et al., who subsequently were awarded the 2006 Nobel Prize in Physiology/Medicine. Subsequent RNAi studies have demonstrated …
RNA interference (RNAi), an accurate and potent gene-silencing method, was first experimentally documented in 1998 in Caenorhabditis …
822 results