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Did you mean factor a protein domains (732 results)?
Targeting transcription factors in cancer - from undruggable to reality.
Bushweller JH. Bushweller JH. Nat Rev Cancer. 2019 Nov;19(11):611-624. doi: 10.1038/s41568-019-0196-7. Epub 2019 Sep 11. Nat Rev Cancer. 2019. PMID: 31511663 Free PMC article. Review.
Mutated or dysregulated transcription factors represent a unique class of drug targets that mediate aberrant gene expression, including blockade of differentiation and cell death gene expression programmes, hallmark properties of cancers. Transcription factor activity is a …
Mutated or dysregulated transcription factors represent a unique class of drug targets that mediate aberrant gene expression, including bloc …
METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes.
Song H, Feng X, Zhang H, Luo Y, Huang J, Lin M, Jin J, Ding X, Wu S, Huang H, Yu T, Zhang M, Hong H, Yao S, Zhao Y, Zhang Z. Song H, et al. Autophagy. 2019 Aug;15(8):1419-1437. doi: 10.1080/15548627.2019.1586246. Epub 2019 Mar 17. Autophagy. 2019. PMID: 30870073 Free PMC article.
We found that METTL3 (methyltransferase like 3) is the primary factor involved in aberrant m(6)A modification. Silencing METTL3 enhances autophagic flux and inhibits apoptosis in H/R-treated cardiomyocytes. ...Abbreviations: ACTB, actin beta; ALKBH5, alkB homolog 5, RNA de …
We found that METTL3 (methyltransferase like 3) is the primary factor involved in aberrant m(6)A modification. Silencing METTL3 enhan …
Blood coagulation factor Va's key interactive residues and regions for prothrombinase assembly and prothrombin binding.
Schreuder M, Reitsma PH, Bos MHA. Schreuder M, et al. J Thromb Haemost. 2019 Aug;17(8):1229-1239. doi: 10.1111/jth.14487. Epub 2019 Jun 17. J Thromb Haemost. 2019. PMID: 31102425 Free PMC article. Review.
Blood coagulation factor Va serves an indispensable role in hemostasis as cofactor for the serine protease factor Xa. ...In this review, an overview of the currently available information on these interactive sites in factor Va is provided, and …
Blood coagulation factor Va serves an indispensable role in hemostasis as cofactor for the serine protease factor Xa. . …
Bright and photostable chemigenetic indicators for extended in vivo voltage imaging.
Abdelfattah AS, Kawashima T, Singh A, Novak O, Liu H, Shuai Y, Huang YC, Campagnola L, Seeman SC, Yu J, Zheng J, Grimm JB, Patel R, Friedrich J, Mensh BD, Paninski L, Macklin JJ, Murphy GJ, Podgorski K, Lin BJ, Chen TW, Turner GC, Liu Z, Koyama M, Svoboda K, Ahrens MB, Lavis LD, Schreiter ER. Abdelfattah AS, et al. Science. 2019 Aug 16;365(6454):699-704. doi: 10.1126/science.aav6416. Epub 2019 Aug 1. Science. 2019. PMID: 31371562
We engineered a GEVI, called Voltron, that uses bright and photostable synthetic dyes instead of protein-based fluorophores, thereby extending the number of neurons imaged simultaneously in vivo by a factor of 10 and enabling imaging for significantly longer duratio …
We engineered a GEVI, called Voltron, that uses bright and photostable synthetic dyes instead of protein-based fluorophores, thereby …
Phase separation of YAP reorganizes genome topology for long-term YAP target gene expression.
Cai D, Feliciano D, Dong P, Flores E, Gruebele M, Porat-Shliom N, Sukenik S, Liu Z, Lippincott-Schwartz J. Cai D, et al. Nat Cell Biol. 2019 Dec;21(12):1578-1589. doi: 10.1038/s41556-019-0433-z. Epub 2019 Dec 2. Nat Cell Biol. 2019. PMID: 31792379 Free PMC article.
Yes-associated protein (YAP) is a transcriptional co-activator that regulates cell proliferation and survival by binding to a select set of enhancers for target gene activation. ...Super-resolution imaging using assay for transposase-accessible chromatin with photoactivate …
Yes-associated protein (YAP) is a transcriptional co-activator that regulates cell proliferation and survival by binding to a select …
Multimerin.
Hayward CP, Kelton JG. Hayward CP, et al. Curr Opin Hematol. 1995 Sep;2(5):339-44. doi: 10.1097/00062752-199502050-00003. Curr Opin Hematol. 1995. PMID: 9372017 Review.
The complementary DNA sequence of multimerin indicates that multimerin is a novel protein, with Arg-Gly-Asp-Ser, coiled-coil, and epidermal growth factor-like domains. ...Following cellular activation, multimerin is released and binds to these cells and the e …
The complementary DNA sequence of multimerin indicates that multimerin is a novel protein, with Arg-Gly-Asp-Ser, coiled-coil, and epi …
Biochemistry, Adiponectin.
Ramakrishnan N, Auger K, Rahimi N, Jialal I. Ramakrishnan N, et al. 2023 Jul 30. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Jul 30. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 30725726 Free Books & Documents.
The HMW is considered to be the most biologically active form of adiponectin. Adiponectin contains two distinct domains; the N-terminal domain is a collagen-like sequence, and the C-terminal globular domain is homologous to the globular complement factor C1q. The C- …
The HMW is considered to be the most biologically active form of adiponectin. Adiponectin contains two distinct domains; the N-termin …
Factor V and protein S as cofactors to activated protein C.
Dahlbäck B. Dahlbäck B. Haematologica. 1997 Jan-Feb;82(1):91-5. Haematologica. 1997. PMID: 9107093 Review.
BACKGROUND AND OBJECTIVE: Activated protein C (APC)-resistance, the most common risk factor for venous thrombosis described so far, is due to a single point mutation in the factor V gene. ...PERSPECTIVES: Recent data suggest that factor V and protei …
BACKGROUND AND OBJECTIVE: Activated protein C (APC)-resistance, the most common risk factor for venous thrombosis described so …
ptFVa (Pseudonaja Textilis Venom-Derived Factor Va) Retains Structural Integrity Following Proteolysis by Activated Protein C.
Schreuder M, Liu X, Cheung KL, Reitsma PH, Nicolaes GAF, Bos MHA. Schreuder M, et al. Arterioscler Thromb Vasc Biol. 2021 Aug;41(8):2263-2276. doi: 10.1161/ATVBAHA.121.316038. Epub 2021 Jun 24. Arterioscler Thromb Vasc Biol. 2021. PMID: 34162230 Free PMC article.
OBJECTIVE: The Australian snake venom ptFV (Pseudonaja textilis venom-derived factor V) variant retains cofactor function despite APC (activated protein C)-dependent proteolysis. Here, we aimed to unravel the mechanistic principles by determining the role of the abs …
OBJECTIVE: The Australian snake venom ptFV (Pseudonaja textilis venom-derived factor V) variant retains cofactor function despite APC …
Factor Va alternative conformation reconstruction using atomic force microscopy.
Chaves RC, Dahmane S, Odorico M, Nicolaes GA, Pellequer JL. Chaves RC, et al. Thromb Haemost. 2014 Dec;112(6):1167-73. doi: 10.1160/TH14-06-0481. Epub 2014 Sep 4. Thromb Haemost. 2014. PMID: 25185589
Collective motions of domains increase the ability of a protein to bind to partner molecules. ...Here, we report the application of a reconstruction protocol, named AFM-assembly, to characterise the conformational variability of the two C domains of human coa …
Collective motions of domains increase the ability of a protein to bind to partner molecules. ...Here, we report the applicati …
413 results