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The thermolabile variant of MTHFR is associated with depression in the British Women's Heart and Health Study and a meta-analysis.
Lewis SJ, Lawlor DA, Davey Smith G, Araya R, Timpson N, Day IN, Ebrahim S. Lewis SJ, et al. Mol Psychiatry. 2006 Apr;11(4):352-60. doi: 10.1038/sj.mp.4001790. Mol Psychiatry. 2006. PMID: 16402130 Review.
However, observational epidemiological studies are plagued by problems of confounding, reverse causality and measurement error. A common polymorphism (C677T) in MTHFR is associated with methyltetrahydrofolate reductase (MTHFR) activity and circulating …
However, observational epidemiological studies are plagued by problems of confounding, reverse causality and measurement error. A common …
Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism, and risk of retinal vein occlusion: an updated meta-analysis.
Li D, Zhou M, Peng X, Sun H. Li D, et al. BMC Ophthalmol. 2014 Nov 27;14:147. doi: 10.1186/1471-2415-14-147. BMC Ophthalmol. 2014. PMID: 25428529 Free PMC article. Review.
BACKGROUND: To evaluate the role of plasma total homocysteine (tHcy) and homozygosity for the thermolabile variant of the methylenetetrahydrofolate reductase (MTHFR) C677T genotype in the risk of retinal vein occlusion (RVO). ...The mean plasma tHcy le …
BACKGROUND: To evaluate the role of plasma total homocysteine (tHcy) and homozygosity for the thermolabile variant of the methylen …
Interaction among folate, riboflavin, genotype, and cancer, with reference to colorectal and cervical cancer.
Powers HJ. Powers HJ. J Nutr. 2005 Dec;135(12 Suppl):2960S-2966S. doi: 10.1093/jn/135.12.2960S. J Nutr. 2005. PMID: 16317155 Free article. Review.
The role of folate in these processes may be modulated by genotype for the common C677T thermolabile variant of methylene tetrahydrofolate reductase (MTHFR), homozygosity for which is associated with lower enzyme activity, lower plasma and red blood cell fola …
The role of folate in these processes may be modulated by genotype for the common C677T thermolabile variant of methylene tetrahydrof …
Homocysteine, hypertension and stroke.
Perry IJ. Perry IJ. J Hum Hypertens. 1999 May;13(5):289-93. doi: 10.1038/sj.jhh.1000803. J Hum Hypertens. 1999. PMID: 10376845 Review.
There are also concerns regarding confounding due to factors associated with hyperhomocysteinemia, including renal impairment, an atherogenic diet and cigarette smoking. Homozygosity for a defective thermolabile variant of MTHFR, a common genetic polymorph …
There are also concerns regarding confounding due to factors associated with hyperhomocysteinemia, including renal impairment, an atherogeni …
Folic acid for the prevention of congenital anomalies.
Hall J, Solehdin F. Hall J, et al. Eur J Pediatr. 1998 Jun;157(6):445-50. doi: 10.1007/s004310050850. Eur J Pediatr. 1998. PMID: 9667396 Review.
Recently adequate folic acid intake in adults has been associated with a reduction in adult cardiovascular disease and some cancers. A common mutation in the 5,10 methylenetetrahydrofolate reductase gene has been identified which produces a thermolabile varia …
Recently adequate folic acid intake in adults has been associated with a reduction in adult cardiovascular disease and some cancers. A commo …
[Molecular genetics of MTHFR: polymorphisms are not all benign].
Leclerc D, Rozen R. Leclerc D, et al. Med Sci (Paris). 2007 Mar;23(3):297-302. doi: 10.1051/medsci/2007233297. Med Sci (Paris). 2007. PMID: 17349292 Free article. Review. French.
Methylenetetrahydrofolate reductase (MTHFR) is a key regulatory enzyme in folate and homocysteine metabolism. ...Shortly thereafter, we identified the 677C-->T variant and showed that it encoded a thermolabile enzyme with reduced activity. Currently …
Methylenetetrahydrofolate reductase (MTHFR) is a key regulatory enzyme in folate and homocysteine metabolism. ...Shortl …
Relevance of folate metabolism in the pathogenesis of colorectal cancer.
Ryan BM, Weir DG. Ryan BM, et al. J Lab Clin Med. 2001 Sep;138(3):164-76. doi: 10.1067/mlc.2001.117161. J Lab Clin Med. 2001. PMID: 11528369 Review.
The epidemiologic and mechanistic evidence linking folate deficiency with carcinogenesis is reviewed, with a particular emphasis on colorectal neoplasia. Methylenetetrahydrofolate reductase (MTHFR) is a critical folate metabolizing enzyme, and a functional …
The epidemiologic and mechanistic evidence linking folate deficiency with carcinogenesis is reviewed, with a particular emphasis on colorect …