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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 170
1964 263
1965 202
1966 235
1967 314
1968 451
1969 474
1970 482
1971 624
1972 660
1973 619
1974 659
1975 562
1976 612
1977 508
1978 548
1979 612
1980 590
1981 615
1982 692
1983 731
1984 836
1985 868
1986 879
1987 1045
1988 1473
1989 1763
1990 1904
1991 2118
1992 2160
1993 2346
1994 2453
1995 2722
1996 2848
1997 3277
1998 3508
1999 3420
2000 3881
2001 4348
2002 4865
2003 4925
2004 5612
2005 5716
2006 6222
2007 6284
2008 6041
2009 6131
2010 6685
2011 7235
2012 7500
2013 8268
2014 8423
2015 8373
2016 9025
2017 9196
2018 8605
2019 8582
2020 9539
2021 10436
2022 9850
2023 9353
2024 2783

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Search Results

204,600 results

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Page 1
Molecular aspects of fructose metabolism and metabolic disease.
Herman MA, Birnbaum MJ. Herman MA, et al. Cell Metab. 2021 Dec 7;33(12):2329-2354. doi: 10.1016/j.cmet.2021.09.010. Epub 2021 Oct 6. Cell Metab. 2021. PMID: 34619074 Free PMC article. Review.
However, when fructose is consumed in excess, these unique properties may contribute to the pathogenesis of cardiometabolic disease. Here, we review the biochemistry, genetics, and physiology of fructose metabolism and consider mechanisms by which excessive fructose consum …
However, when fructose is consumed in excess, these unique properties may contribute to the pathogenesis of cardiometabolic disease. …
Chronic tissue inflammation and metabolic disease.
Lee YS, Olefsky J. Lee YS, et al. Genes Dev. 2021 Mar 1;35(5-6):307-328. doi: 10.1101/gad.346312.120. Genes Dev. 2021. PMID: 33649162 Free PMC article. Review.
It is now widely recognized that chronic, subacute tissue inflammation is a major etiologic component of the pathogenesis of insulin resistance and metabolic dysfunction in obesity. Here, we summarize recent advances in our understanding of immunometabolism. We discuss the …
It is now widely recognized that chronic, subacute tissue inflammation is a major etiologic component of the pathogenesis of insulin resista …
Epitranscriptomics in metabolic disease.
Matsumura Y, Wei FY, Sakai J. Matsumura Y, et al. Nat Metab. 2023 Mar;5(3):370-384. doi: 10.1038/s42255-023-00764-4. Epub 2023 Mar 23. Nat Metab. 2023. PMID: 36959512 Review.
Importantly, genetic variations or environmental perturbations of epitranscriptome modifiers (that is, writers, erasers and readers) are associated with obesity and metabolic diseases, such as type 2 diabetes. The epitranscriptome is closely coupled to epigenetic si …
Importantly, genetic variations or environmental perturbations of epitranscriptome modifiers (that is, writers, erasers and readers) are ass …
Autophagy in metabolic disease and ageing.
Kitada M, Koya D. Kitada M, et al. Nat Rev Endocrinol. 2021 Nov;17(11):647-661. doi: 10.1038/s41574-021-00551-9. Epub 2021 Sep 10. Nat Rev Endocrinol. 2021. PMID: 34508250 Review.
Impairment of autophagy results in further aggravation of diabetes-related metabolic derangements in insulin target tissues, including the liver, skeletal muscle and adipose tissue, as well as in pancreatic beta-cells. This Review summarizes the role of autophagy in the pa …
Impairment of autophagy results in further aggravation of diabetes-related metabolic derangements in insulin target tissues, includin …
Adipogenesis.
Sarjeant K, Stephens JM. Sarjeant K, et al. Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a008417. doi: 10.1101/cshperspect.a008417. Cold Spring Harb Perspect Biol. 2012. PMID: 22952395 Free PMC article. Review.
The general functions and cellular origins of adipose tissue and how the modulation of adipocyte development pertains to metabolic disease states will also be considered....
The general functions and cellular origins of adipose tissue and how the modulation of adipocyte development pertains to metabolic …
Gut Microbiota as a Trigger for Metabolic Inflammation in Obesity and Type 2 Diabetes.
Scheithauer TPM, Rampanelli E, Nieuwdorp M, Vallance BA, Verchere CB, van Raalte DH, Herrema H. Scheithauer TPM, et al. Front Immunol. 2020 Oct 16;11:571731. doi: 10.3389/fimmu.2020.571731. eCollection 2020. Front Immunol. 2020. PMID: 33178196 Free PMC article. Review.
First, we will summarize major findings about immunological and gut microbial changes in these metabolic diseases. Next, we will give a detailed view on how gut microbial changes have been implicated in low-grade inflammation. Lastly, we will critically discuss clin …
First, we will summarize major findings about immunological and gut microbial changes in these metabolic diseases. Next, we wi …
Brain insulin signalling in metabolic homeostasis and disease.
Scherer T, Sakamoto K, Buettner C. Scherer T, et al. Nat Rev Endocrinol. 2021 Aug;17(8):468-483. doi: 10.1038/s41574-021-00498-x. Epub 2021 Jun 9. Nat Rev Endocrinol. 2021. PMID: 34108679 Review.
Studies performed in rodents, non-human primates and humans over more than five decades using intracerebroventricular, direct hypothalamic or intranasal application of insulin provide evidence that brain insulin action might reduce food intake and, more importantly, regulates ene …
Studies performed in rodents, non-human primates and humans over more than five decades using intracerebroventricular, direct hypothalamic o …
DNA damage response and metabolic disease.
Shimizu I, Yoshida Y, Suda M, Minamino T. Shimizu I, et al. Cell Metab. 2014 Dec 2;20(6):967-77. doi: 10.1016/j.cmet.2014.10.008. Epub 2014 Nov 13. Cell Metab. 2014. PMID: 25456739 Free article. Review.
Accumulation of DNA damage has been linked to the process of aging and to the onset of age-related diseases including diabetes. Studies on progeroid syndromes have suggested that the DNA damage response is involved in regulation of metabolic homeostasis. ...This rev …
Accumulation of DNA damage has been linked to the process of aging and to the onset of age-related diseases including diabetes. Studi …
Cardio-Metabolic Benefits of Plant-Based Diets.
Kahleova H, Levin S, Barnard N. Kahleova H, et al. Nutrients. 2017 Aug 9;9(8):848. doi: 10.3390/nu9080848. Nutrients. 2017. PMID: 28792455 Free PMC article. Review.
Cardio-metabolic disease, namely ischemic heart disease, stroke, obesity, and type 2 diabetes, represent substantial health and economic burdens. ...The use of plant-based diets as a means of prevention and treatment of cardio-metabolic disease …
Cardio-metabolic disease, namely ischemic heart disease, stroke, obesity, and type 2 diabetes, represent substantial he …
204,600 results
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