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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1998 15
1999 21
2000 39
2001 40
2002 32
2003 64
2004 83
2005 75
2006 90
2007 100
2008 129
2009 138
2010 125
2011 145
2012 123
2013 183
2014 210
2015 191
2016 148
2017 163
2018 152
2019 174
2020 206
2021 219
2022 164
2023 153
2024 57

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2,893 results

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Page 1
PTEN in Autism and Neurodevelopmental Disorders.
Rademacher S, Eickholt BJ. Rademacher S, et al. Cold Spring Harb Perspect Med. 2019 Nov 1;9(11):a036780. doi: 10.1101/cshperspect.a036780. Cold Spring Harb Perspect Med. 2019. PMID: 31427284 Free PMC article. Review.
Phosphatase and tensin homolog (PTEN) is a classical tumor suppressor that antagonizes phosphatidylinositol 3-phosphate kinase (PI3K)/AKT signaling. ...To investigate PTEN's role during neurodevelopment and its implication for autism, several conditional Pten …
Phosphatase and tensin homolog (PTEN) is a classical tumor suppressor that antagonizes phosphatidylinositol 3-phosphate kinase (PI3K) …
PTEN: Tumor Suppressor and Metabolic Regulator.
Chen CY, Chen J, He L, Stiles BL. Chen CY, et al. Front Endocrinol (Lausanne). 2018 Jul 9;9:338. doi: 10.3389/fendo.2018.00338. eCollection 2018. Front Endocrinol (Lausanne). 2018. PMID: 30038596 Free PMC article. Review.
In this review, we introduced the discovery of PTEN, the PTEN-regulated canonical and nuclear signals, and PTEN regulation. We then focused on the role of PTEN and PTEN-regulated signals in metabolic regulation. This included the role of PTEN …
In this review, we introduced the discovery of PTEN, the PTEN-regulated canonical and nuclear signals, and PTEN regulat …
Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria.
Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E. Pilarski R, et al. J Natl Cancer Inst. 2013 Nov 6;105(21):1607-16. doi: 10.1093/jnci/djt277. Epub 2013 Oct 17. J Natl Cancer Inst. 2013. PMID: 24136893 Review.
BACKGROUND: PTEN hamartoma tumor syndrome (PHTS) refers to a spectrum of disorders caused by mutations in the phosphatase and tensin homolog (PTEN) gene. Diagnostic criteria for Cowden syndrome, the principal PTEN-related disorder, were first established in 1 …
BACKGROUND: PTEN hamartoma tumor syndrome (PHTS) refers to a spectrum of disorders caused by mutations in the phosphatase and tensin …
The functions and regulation of the PTEN tumour suppressor: new modes and prospects.
Lee YR, Chen M, Pandolfi PP. Lee YR, et al. Nat Rev Mol Cell Biol. 2018 Sep;19(9):547-562. doi: 10.1038/s41580-018-0015-0. Nat Rev Mol Cell Biol. 2018. PMID: 29858604 Review.
Regulation of PTEN has therefore emerged as a subject of intense research in tumour biology. Recent discoveries, including the existence of distinct PTEN isoforms and the ability of PTEN to form dimers, have brought to light new modes of PTEN function …
Regulation of PTEN has therefore emerged as a subject of intense research in tumour biology. Recent discoveries, including the existe …
PTEN.
Worby CA, Dixon JE. Worby CA, et al. Annu Rev Biochem. 2014;83:641-69. doi: 10.1146/annurev-biochem-082411-113907. Annu Rev Biochem. 2014. PMID: 24905788 Review.
The importance of PTEN in cellular function is underscored by the frequency of its deregulation in cancer. PTEN tumor-suppressor activity depends largely on its lipid phosphatase activity, which opposes PI3K/AKT activation. ...
The importance of PTEN in cellular function is underscored by the frequency of its deregulation in cancer. PTEN tumor-suppress …
Regulating tumor suppressor genes: post-translational modifications.
Chen L, Liu S, Tao Y. Chen L, et al. Signal Transduct Target Ther. 2020 Jun 10;5(1):90. doi: 10.1038/s41392-020-0196-9. Signal Transduct Target Ther. 2020. PMID: 32532965 Free PMC article. Review.
Three important tumor suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted on chromosome ten (PTEN) are functionally associated and they regulated by post-translational modification (PTMs) as well. ...We here review the necessity, characte …
Three important tumor suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted on chromosome ten (PTEN) …
Mechanisms of PTEN loss in cancer: It's all about diversity.
Álvarez-Garcia V, Tawil Y, Wise HM, Leslie NR. Álvarez-Garcia V, et al. Semin Cancer Biol. 2019 Dec;59:66-79. doi: 10.1016/j.semcancer.2019.02.001. Epub 2019 Feb 7. Semin Cancer Biol. 2019. PMID: 30738865 Review.
Although the mechanisms by which PTEN function is disrupted are diverse, the most frequently observed events are deletion of a single gene copy of PTEN and gene silencing, usually observed in tumours with little or no PTEN protein detectable by immunohistoche …
Although the mechanisms by which PTEN function is disrupted are diverse, the most frequently observed events are deletion of a single …
The Clinical Spectrum of PTEN Mutations.
Yehia L, Keel E, Eng C. Yehia L, et al. Annu Rev Med. 2020 Jan 27;71:103-116. doi: 10.1146/annurev-med-052218-125823. Epub 2019 Aug 21. Annu Rev Med. 2020. PMID: 31433956 Review.
PTEN is a tumor suppressor gene that classically dampens the PI3K/AKT/mTOR growth-promoting signaling cascade. PTEN dysfunction causes dysregulation of this and other pathways, resulting in overgrowth. ...
PTEN is a tumor suppressor gene that classically dampens the PI3K/AKT/mTOR growth-promoting signaling cascade. PTEN dysfunctio …
PTEN and Gynecological Cancers.
Nero C, Ciccarone F, Pietragalla A, Scambia G. Nero C, et al. Cancers (Basel). 2019 Sep 28;11(10):1458. doi: 10.3390/cancers11101458. Cancers (Basel). 2019. PMID: 31569439 Free PMC article. Review.
PTEN is a tumour suppressor gene, and its loss of function is frequently observed in both heritable and sporadic cancers. ...Here, we present the most significant findings on PTEN in gynaecological cancers (ovarian, endometrial, cervical, vulvar and uterine cancer) …
PTEN is a tumour suppressor gene, and its loss of function is frequently observed in both heritable and sporadic cancers. ...Here, we …
PTEN in kidney cancer: A review and meta-analysis.
Que WC, Qiu HQ, Cheng Y, Liu MB, Wu CY. Que WC, et al. Clin Chim Acta. 2018 May;480:92-98. doi: 10.1016/j.cca.2018.01.031. Epub 2018 Feb 2. Clin Chim Acta. 2018. PMID: 29408173 Review.

For the survival outcome, the result suggested that shorter overall survival (OS) was correlated with low PTEN expression (HR = 0.57, 95% CIs: 0.45-0.74, P < 0.0001). The meta-analysis indicated a significantly increased risk of tumorigenesis in the PTEN low-leve

…
For the survival outcome, the result suggested that shorter overall survival (OS) was correlated with low PTEN expression (HR = 0.57, …
2,893 results