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Year Number of Results
1993 1
1997 10
1998 36
1999 23
2000 26
2001 27
2002 15
2003 18
2004 19
2005 16
2006 25
2007 30
2008 25
2009 17
2010 33
2011 39
2012 49
2013 50
2014 48
2015 45
2016 38
2017 46
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2020 41
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2023 48
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806 results

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Page 1
WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition.
Lee YR, Yehia L, Kishikawa T, Ni Y, Leach B, Zhang J, Panch N, Liu J, Wei W, Eng C, Pandolfi PP. Lee YR, et al. N Engl J Med. 2020 May 28;382(22):2103-2116. doi: 10.1056/NEJMoa1914919. N Engl J Med. 2020. PMID: 32459922 Free PMC article.
BACKGROUND: Patients with PTEN hamartoma tumor syndrome (PHTS) have germline mutations in the tumor-suppressor gene encoding phosphatase and tensin homologue (PTEN). Such mutations have been associated with a hereditary predisposition to multiple …
BACKGROUND: Patients with PTEN hamartoma tumor syndrome (PHTS) have germline mutations in the tumor-suppressor gene enc …
Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria.
Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E. Pilarski R, et al. J Natl Cancer Inst. 2013 Nov 6;105(21):1607-16. doi: 10.1093/jnci/djt277. Epub 2013 Oct 17. J Natl Cancer Inst. 2013. PMID: 24136893 Review.
BACKGROUND: PTEN hamartoma tumor syndrome (PHTS) refers to a spectrum of disorders caused by mutations in the phosphatase and tensin homolog (PTEN) gene. Diagnostic criteria for Cowden syndrome, the principal PTEN-related disorder, …
BACKGROUND: PTEN hamartoma tumor syndrome (PHTS) refers to a spectrum of disorders caused by mutations in the phosphata …
Cowden Disease: A Review.
Magaña M, Landeta-Sa AP, López-Flores Y. Magaña M, et al. Am J Dermatopathol. 2022 Oct 1;44(10):705-717. doi: 10.1097/DAD.0000000000002234. Am J Dermatopathol. 2022. PMID: 36122333 Review.
PTEN hamartoma tumor syndrome (PTHS) includes diseases with germline pathogenic variants in the PTEN gene. ...Patients present benign and, malignant neoplasms in multiple organs, mostly breast and thyroid. The skin is the organ affected most con …
PTEN hamartoma tumor syndrome (PTHS) includes diseases with germline pathogenic variants in the PTEN gene. ...Pa …
High cumulative risks of cancer in patients with PTEN hamartoma tumour syndrome.
Bubien V, Bonnet F, Brouste V, Hoppe S, Barouk-Simonet E, David A, Edery P, Bottani A, Layet V, Caron O, Gilbert-Dussardier B, Delnatte C, Dugast C, Fricker JP, Bonneau D, Sevenet N, Longy M, Caux F; French Cowden Disease Network. Bubien V, et al. J Med Genet. 2013 Apr;50(4):255-63. doi: 10.1136/jmedgenet-2012-101339. Epub 2013 Jan 18. J Med Genet. 2013. PMID: 23335809 Free article.
BACKGROUND: PTEN hamartoma tumour syndrome (PHTS) encompasses several clinical syndromes with germline mutations in the PTEN tumour suppressor gene, including Cowden syndrome which is characterised by an increased risk of breast and thyro …
BACKGROUND: PTEN hamartoma tumour syndrome (PHTS) encompasses several clinical syndromes with germline mutations in the …
The Role of PTEN in Innate and Adaptive Immunity.
Taylor H, Laurence ADJ, Uhlig HH. Taylor H, et al. Cold Spring Harb Perspect Med. 2019 Dec 2;9(12):a036996. doi: 10.1101/cshperspect.a036996. Cold Spring Harb Perspect Med. 2019. PMID: 31501268 Free PMC article. Review.
The lipid and protein phosphatase and tensin homolog (PTEN) controls the differentiation and activation of multiple immune cells. ...Although most patients with PTEN hamartoma tumor syndrome (PHTS) have no immunological symptoms, a subclinical i …
The lipid and protein phosphatase and tensin homolog (PTEN) controls the differentiation and activation of multiple immune cel …
PTEN in Hereditary and Sporadic Cancer.
Ngeow J, Eng C. Ngeow J, et al. Cold Spring Harb Perspect Med. 2020 Apr 1;10(4):a036087. doi: 10.1101/cshperspect.a036087. Cold Spring Harb Perspect Med. 2020. PMID: 31570378 Free PMC article. Review.
Germline pathogenic phosphatase and tensin homolog (PTEN) mutations cause PTEN hamartoma tumor syndrome (PHTS), characterized by various benign and malignant tumors of the thyroid, breast, endometrium, and other organs. ...In this review, we highlight …
Germline pathogenic phosphatase and tensin homolog (PTEN) mutations cause PTEN hamartoma tumor syndrome (PHTS), …
Epilepsy in Cowden syndrome: beyond Lhermitte-Duclos disease.
Serôdio M, Calvão-Pires P, Zhang D, Sá F. Serôdio M, et al. Acta Neurol Belg. 2023 Oct;123(5):2035-2037. doi: 10.1007/s13760-022-02106-9. Epub 2022 Oct 2. Acta Neurol Belg. 2023. PMID: 36184653 No abstract available.
Germline mutation of the PTEN gene in a Japanese patient with Cowden's disease.
Kato N, Kimura K, Sugawara H, Aoyagi S, Ikeda T, Horii A. Kato N, et al. Int J Oncol. 2001 May;18(5):1017-22. doi: 10.3892/ijo.18.5.1017. Int J Oncol. 2001. PMID: 11295050 Review.
Cowden's disease (CD) is an autosomal dominant disorder which confers a high susceptibility to diverse benign and malignant tumors. ...Recently, germline mutations of this gene were also found in patients with CD, and it is now recognized as a gene responsible for t …
Cowden's disease (CD) is an autosomal dominant disorder which confers a high susceptibility to diverse benign and malignant tu …
Gastrointestinal manifestations in PTEN hamartoma tumor syndrome.
D'Ermo G, Genuardi M. D'Ermo G, et al. Best Pract Res Clin Gastroenterol. 2022 Jun-Aug;58-59:101792. doi: 10.1016/j.bpg.2022.101792. Epub 2022 Mar 17. Best Pract Res Clin Gastroenterol. 2022. PMID: 35988965 Review.
The PTEN hamartoma tumor syndrome (PHTS) is a heterogeneous set of multisystem disorders caused by germline pathogenic variants in the PTEN tumor suppressor gene. ...Evidence of involvement of the GI tract has accrued over time, leading to the incorpor …
The PTEN hamartoma tumor syndrome (PHTS) is a heterogeneous set of multisystem disorders caused by germline pathogenic …
Imaging of PTEN-related abnormalities in the central nervous system.
Dhamija R, Hoxworth JM. Dhamija R, et al. Clin Imaging. 2020 Apr;60(2):180-185. doi: 10.1016/j.clinimag.2019.12.006. Epub 2019 Dec 24. Clin Imaging. 2020. PMID: 31927175 Review.
PTEN mutations have been associated with multiple abnormalities in the central nervous system, and a number of clinical phenotypes are now attributed to germline PTEN mutations, collectively referred to as PTEN hamartoma tumor syndrome (P …
PTEN mutations have been associated with multiple abnormalities in the central nervous system, and a number of clinical phenot …
806 results