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Page 1
Ghrelin and Growth.
Perchard R, Clayton PE. Perchard R, et al. Endocr Dev. 2017;32:74-86. doi: 10.1159/000475732. Epub 2017 Aug 15. Endocr Dev. 2017. PMID: 28873385 Review.
Ghrelin is a pleiotropic hormone, whose effect on growth hormone secretion, through the growth hormone secretagogue (GHS) receptor, is one of its many actions. ...These include constitutional delay in growth and puber
Ghrelin is a pleiotropic hormone, whose effect on growth hormone secretion, through the growth hormone
Genetics of GHRH, GHRH-receptor, GH and GH-receptor: its impact on pharmacogenetics.
Mullis PE. Mullis PE. Best Pract Res Clin Endocrinol Metab. 2011 Feb;25(1):25-41. doi: 10.1016/j.beem.2010.06.006. Best Pract Res Clin Endocrinol Metab. 2011. PMID: 21396573 Review.
Because Insulin-like-Growth Factor-I (IGF-I) plays a pivotal role, GHD could also be considered as a form of IGF-I deficiency (IGFD). ...However, although transcription factors regulating the pituitary gland development may cause multiple pituitary hormone
Because Insulin-like-Growth Factor-I (IGF-I) plays a pivotal role, GHD could also be considered as a form of IGF-I deficiency
Clinical pharmacology of human growth hormone and its secretagogues.
Root AW, Root MJ. Root AW, et al. Curr Drug Targets Immune Endocr Metabol Disord. 2002 Apr;2(1):27-52. Curr Drug Targets Immune Endocr Metabol Disord. 2002. PMID: 12477295 Review.
Both the production and secretion of GH are stimulated by hypothalamic GH-releasing hormone (GHRH) and by the endogenous GH secretagogue (GHS) ghrelin, a product of the oxyntic cells located within the fundus of the stomach. ...The availability of large quant …
Both the production and secretion of GH are stimulated by hypothalamic GH-releasing hormone (GHRH) and by the endogenous GH secret
MECHANISMS IN ENDOCRINOLOGY: The multiple facets of GHRH/GH/IGF-I axis: lessons from lifetime, untreated, isolated GH deficiency due to a GHRH receptor gene mutation.
Aguiar-Oliveira MH, Souza AHO, Oliveira CRP, Campos VC, Oliveira-Neto LA, Salvatori R. Aguiar-Oliveira MH, et al. Eur J Endocrinol. 2017 Aug;177(2):R85-R97. doi: 10.1530/EJE-16-1047. Epub 2017 Apr 20. Eur J Endocrinol. 2017. PMID: 28428227 Review.
Twenty years ago, we described kindred of 105 individuals with isolated GH deficiency (IGHD) in Itabaianinha County, in northeast Brazil, carrying a homozygous mutation in the GH-releasing hormone receptor gene. ...The most striking physical findings of these …
Twenty years ago, we described kindred of 105 individuals with isolated GH deficiency (IGHD) in Itabaianinha County, in northeast Bra …
Ghrelin receptor mutations--too little height and too much hunger.
Holst B, Schwartz TW. Holst B, et al. J Clin Invest. 2006 Mar;116(3):637-41. doi: 10.1172/JCI27999. J Clin Invest. 2006. PMID: 16511600 Free PMC article. Review.
The ghrelin receptor is known from in vitro studies to signal in the absence of the hormone ghrelin at almost 50% of its maximal capacity. ...In this issue of the JCI, Pantel et al. find that a natural mutation in the ghrelin receptor, Al …
The ghrelin receptor is known from in vitro studies to signal in the absence of the hormone ghrelin at almost 50 …
Spectrum of insulin-like growth factor deficiency.
Wit JM, Oostdijk W, Losekoot M. Wit JM, et al. Endocr Dev. 2012;23:30-41. doi: 10.1159/000341739. Epub 2012 Nov 23. Endocr Dev. 2012. PMID: 23182818 Review.
There are eight known genetic causes of short stature characterized by low serum IGF-1 (IGF-1 deficiency, IGFD) and normal GH secretion. ...Most cases with a homozygous IGF1 defect are very short, microcephalic, and deaf, but heterozygous mutations may …
There are eight known genetic causes of short stature characterized by low serum IGF-1 (IGF-1 deficiency, IGFD) and nor …
Growth hormone-releasing hormone and growth hormone-releasing peptide as therapeutic agents to enhance growth hormone secretion in disease and aging.
Thorner MO, Chapman IM, Gaylinn BD, Pezzoli SS, Hartman ML. Thorner MO, et al. Recent Prog Horm Res. 1997;52:215-44; discussion 244-6. Recent Prog Horm Res. 1997. PMID: 9238854 Review.
Mutations of the GHRH receptor lead to GH deficiency and short stature. This indicates the essential role of GHRH in regulation of GH secretion. ...These GH secretagogues may have a therapeutic role in short stature and adult GH defici
Mutations of the GHRH receptor lead to GH deficiency and short stature. This indicates the essential role of GHR …
Indications, limitations and pitfalls in the determination of human growth hormone, IGF-I and their binding proteins.
Laron Z, Bidlingmaier M, Strasburger CJ. Laron Z, et al. Pediatr Endocrinol Rev. 2007 Oct;5 Suppl 1:555-69. Pediatr Endocrinol Rev. 2007. PMID: 18167466 Review.
Deviations from normal growth are a major part of Pediatric Endocrinology. The principal post-natal growth promoting hormones are pituitary growth hormone (GH) and insulin-like growth factor-I (IGF-I). ...As both hGH and IGF-I immunoassay measur …
Deviations from normal growth are a major part of Pediatric Endocrinology. The principal post-natal growth promoting hormones …