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Did you mean sirna[All Fields] (131,490 results)?
Functions and regulation of RNA editing by ADAR deaminases.
Nishikura K. Nishikura K. Annu Rev Biochem. 2010;79:321-49. doi: 10.1146/annurev-biochem-060208-105251. Annu Rev Biochem. 2010. PMID: 20192758 Free PMC article. Review.
Although the biological significance of noncoding RNA editing remains largely unknown, several possibilities, including its role in the control of endogenous short interfering RNAs (esiRNAs), have been proposed. Furthermore, recent studies have revealed that the biogenesis …
Although the biological significance of noncoding RNA editing remains largely unknown, several possibilities, including its role in the cont …
Pseudogene-derived endogenous siRNAs and their function.
Chan WL, Chang JG. Chan WL, et al. Methods Mol Biol. 2014;1167:227-39. doi: 10.1007/978-1-4939-0835-6_15. Methods Mol Biol. 2014. PMID: 24823781 Review.
Pseudogenes were once considered genomic fossils, but recent studies indicate that they may function as gene regulators through the generation of endogenous small interfering RNAs (esiRNAs), antisense RNAs, and decoys for microRNAs. In this review, we summarize pseudogene …
Pseudogenes were once considered genomic fossils, but recent studies indicate that they may function as gene regulators through the generati …
A polyacrylamide microbead-integrated chip for the large-scale manufacture of ready-to-use esiRNA.
Huang H, Chang Q, Sun C, Yin S, Li J, Xi JJ. Huang H, et al. Lab Chip. 2011 Mar 21;11(6):1036-40. doi: 10.1039/c0lc00564a. Epub 2011 Jan 28. Lab Chip. 2011. PMID: 21274477
These performances significantly hamper the application of esiRNAs on a large-scale level. In this study, we present a polymer microbead-integrated chip capable of the large-scale manufacture of esiRNA in a convenient and robust manner. ...Thus the esiRNA, al …
These performances significantly hamper the application of esiRNAs on a large-scale level. In this study, we present a polymer microb …
Drosophila melanogaster retrotransposon and inverted repeat-derived endogenous siRNAs are differentially processed in distinct cellular locations.
Harrington AW, McKain MR, Michalski D, Bauer KM, Daugherty JM, Steiniger M. Harrington AW, et al. BMC Genomics. 2017 Apr 17;18(1):304. doi: 10.1186/s12864-017-3692-8. BMC Genomics. 2017. PMID: 28415970 Free PMC article.
RNAi-depletion of CCC components Symplekin and CPSF73 causes perturbations in esiRNA abundance that correlate with fluctuations in retrotransposon and hairpin esiRNA precursor levels. ...CONCLUSIONS: Together, these observations support a novel mechanism in which di …
RNAi-depletion of CCC components Symplekin and CPSF73 causes perturbations in esiRNA abundance that correlate with fluctuations in re …
Downregulation of PIK3CA via antibody-esiRNA-complexes suppresses human xenograft tumor growth.
Bäumer N, Rehkämper J, Appel N, Terheyden L, Hartmann W, Wardelmann E, Buchholz F, Müller-Tidow C, Berdel WE, Bäumer S. Bäumer N, et al. PLoS One. 2018 Jul 12;13(7):e0200163. doi: 10.1371/journal.pone.0200163. eCollection 2018. PLoS One. 2018. PMID: 30001368 Free PMC article.
We chose heterogeneous endoribonuclease-prepared siRNA pools (esiRNAs) against the frequently mutated genes PIK3CA and KRAS and coupled them to the anti-EGFR antibody cetuximab, which was internalized specifically into the tumor cells. esiRNA pools have been shown t …
We chose heterogeneous endoribonuclease-prepared siRNA pools (esiRNAs) against the frequently mutated genes PIK3CA and KRAS and coupl …
Expression profiling of c-kit and its impact after esiRNA silencing during gonadal development in catfish.
Laldinsangi C, Senthilkumaran B. Laldinsangi C, et al. Gen Comp Endocrinol. 2018 Sep 15;266:38-51. doi: 10.1016/j.ygcen.2018.04.004. Epub 2018 Apr 3. Gen Comp Endocrinol. 2018. PMID: 29625123
In vitro and in vivo induction using human chorionic gonadotropin elevated the expression of c-kit indicating the regulatory influence of hypothalamo-hypophyseal axis. In vivo transient gene silencing using c-kit-esiRNA in adult catfish during gonadal recrudescence showed …
In vitro and in vivo induction using human chorionic gonadotropin elevated the expression of c-kit indicating the regulatory influence of hy …
Biogenesis of small RNAs in animals.
Kim VN, Han J, Siomi MC. Kim VN, et al. Nat Rev Mol Cell Biol. 2009 Feb;10(2):126-39. doi: 10.1038/nrm2632. Nat Rev Mol Cell Biol. 2009. PMID: 19165215 Review.
Various small RNAs of distinctive characteristics have been found and can be classified into three classes based on their biogenesis mechanism and the type of Argonaute protein that they are associated with: microRNAs (miRNAs), endogenous small interfering RNAs (endo-siRNAs or …
Various small RNAs of distinctive characteristics have been found and can be classified into three classes based on their biogenesis mechani …
MISSION esiRNA for RNAi screening in mammalian cells.
Theis M, Buchholz F. Theis M, et al. J Vis Exp. 2010 May 12;(39):2008. doi: 10.3791/2008. J Vis Exp. 2010. PMID: 20467416 Free PMC article.
Thereby, a diverse pool of siRNA-like oligonucleotides is produced which is also known as endoribonuclease-prepared siRNA or esiRNA. A comparison of efficacy of chemically derived siRNAs and esiRNAs shows that both triggers are potent in target-gene silencing. ...Ma …
Thereby, a diverse pool of siRNA-like oligonucleotides is produced which is also known as endoribonuclease-prepared siRNA or esiRNA. …
Involvement of PU.1 in mouse adar-1 gene transcription induced by high-dose esiRNA.
Wu T, Zhao Y, Hao Z, Zhao H, Wang W. Wu T, et al. Int J Biol Macromol. 2009 Aug 1;45(2):157-62. doi: 10.1016/j.ijbiomac.2009.04.021. Epub 2009 May 5. Int J Biol Macromol. 2009. PMID: 19422845
Our results suggest that transcription factor PU.1, could bind to the adar-1 promoter and play a key role in activating transcription of gene induced by high-dose esiRNAs....
Our results suggest that transcription factor PU.1, could bind to the adar-1 promoter and play a key role in activating transcription of gen …
esiRNA to eri-1 and adar-1 genes improving high doses of c-myc-directed esiRNA effect on mouse melanoma growth inhibition.
Hong J, Zhao Y, Li Z, Huang W. Hong J, et al. Biochem Biophys Res Commun. 2007 Sep 21;361(2):373-8. doi: 10.1016/j.bbrc.2007.07.003. Epub 2007 Jul 16. Biochem Biophys Res Commun. 2007. PMID: 17658462
In our preliminary study, we intraperitoneally injected different doses of c-myc-directed esiRNA (esic-MYC, c-myc-directed Escherichia coli expressed and enzyme digested siRNA) into C57BL6/6J mice with bearing B16 melanoma to investigate the inhibitory effect of esic-MYC o …
In our preliminary study, we intraperitoneally injected different doses of c-myc-directed esiRNA (esic-MYC, c-myc-directed Escherichi …
90 results