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News: A New Piece in the HIV Replication... (The Scientist) - Behind the headlines

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Media coverage of health and science topics

The Scientist Feb. 14, 2024

A New Piece in the HIV Replication Puzzle

A host lipid-modifying enzyme plays a key role in HIV envelope formation, viral maturation, and infectivity. 

Read more at The Scientist

Behind the headlines

Research findings and data from the National Library of Medicine

PubMed articles

Proc Natl Acad Sci U S A JULY 11, 2023

Inhibition of neutral sphingomyelinase 2 impairs HIV-1 envelope formation and substantially delays or eliminates viral rebound

SW Yoo et al

Although HIV-1 Gag is known to drive viral assembly and budding, the precise mechanisms by which the lipid composition of the plasma membrane is remodeled during assembly …

Ann Neurol JAN. 1, 2004

Perturbation of sphingolipid metabolism and ceramide production in HIV-dementia

NJ Haughey et al

Infection by the human immunodeficiency virus type 1 (HIV-1) often results in neurological dysfunction including HIV dementia (HIVD). Alterations in cytokine and redox ba …

Proc Natl Acad Sci U S A JULY 11, 2023

Neutral sphingomyelinase 2 is required for HIV-1 maturation

AA Waheed et al

HIV-1 assembly occurs at the inner leaflet of the plasma membrane (PM) in highly ordered membrane microdomains. The size and stability of membrane microdomains is regulat …

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