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What Paraspeckles Can Teach Us About Basic Cell Biology
Discovering a new type of subnuclear body taught me how pursuing the unexpected can lead to new insights--in this case, about long noncoding RNAs and liquid-liquid phase separation in cells.
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PubMed articles
Paraspeckles: a novel nuclear domain
We have identified a novel nuclear compartment, termed paraspeckles, found in both primary and transformed human cells. Paraspeckles contain at least three RNA binding pr …
P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles in an RNA-dependent manner
P54nrb is a protein implicated in multiple nuclear processes whose specific functions may correlate with its presence at different nuclear locations. Here we characterize …
Regulating gene expression through RNA nuclear retention
Multiple mechanisms have evolved to regulate the eukaryotic genome. We have identified CTN-RNA, a mouse tissue-specific approximately 8 kb nuclear-retained poly(A)+ RNA t …
An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles
NEAT1 RNA, a highly abundant 4 kb ncRNA, is retained in nuclei in approximately 10 to 20 large foci that we show are completely coincident with paraspeckles, nuclear doma …
MEN epsilon/beta nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles
Studies of the transcriptional output of the human and mouse genomes have revealed that there are many more transcripts produced than can be accounted for by predicted pr …
MENepsilon/beta noncoding RNAs are essential for structural integrity of nuclear paraspeckles
Recent transcriptome analyses have shown that thousands of noncoding RNAs (ncRNAs) are transcribed from mammalian genomes. Although the number of functionally annotated n …
Highly ordered spatial organization of the structural long noncoding NEAT1 RNAs within paraspeckle nuclear bodies
Paraspeckles (PSPs) are nuclear bodies associated with the retention in the nucleus of specific mRNAs. Two isoforms of a long noncoding RNA (NEAT1_v1/Menε and NEAT1_v2/Me …
Structural, super-resolution microscopy analysis of paraspeckle nuclear body organization
Paraspeckles are nuclear bodies built on the long noncoding RNA Neat1, which regulates a variety of physiological processes including cancer progression and corpus luteum …
Functional Domains of NEAT1 Architectural lncRNA Induce Paraspeckle Assembly through Phase Separation
A class of long noncoding RNAs (lncRNAs) has architectural functions in nuclear body construction; however, specific RNA domains dictating their architectural functions r …
Paraspeckles are subpopulation-specific nuclear bodies that are not essential in mice
Nuclei of higher organisms are well structured and have multiple, distinct nuclear compartments or nuclear bodies. Paraspeckles are recently identified mammal-specific nu …
The lncRNA Neat1 is required for corpus luteum formation and the establishment of pregnancy in a subpopulation of mice
Neat1 is a non-protein-coding RNA that serves as an architectural component of the nuclear bodies known as paraspeckles. Although cell-based studies indicate that Neat1 i …
Genome-wide screening of NEAT1 regulators reveals cross-regulation between paraspeckles and mitochondria
The long noncoding RNA NEAT1 (nuclear enriched abundant transcript 1) nucleates the formation of paraspeckles, which constitute a type of nuclear body with multiple roles …
NEAT1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodies
Paraspeckles are subnuclear structures formed around nuclear paraspeckle assembly transcript 1 (NEAT1)/MENε/β long noncoding RNA (lncRNA). Here we show that paraspeckles …
p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity
In a search for mediators of the p53 tumor suppressor pathway, which induces pleiotropic and often antagonistic cellular responses, we identified the long noncoding RNA ( …
Alternative 3'-end processing of long noncoding RNA initiates construction of nuclear paraspeckles
Paraspeckles are unique subnuclear structures built around a specific long noncoding RNA, NEAT1, which is comprised of two isoforms produced by alternative 3'-end process …
Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles
Prion-like domains (PLDs) are low complexity sequences found in RNA binding proteins associated with the neurodegenerative disorder amyotrophic lateral sclerosis. Recentl …
The structure of human SFPQ reveals a coiled-coil mediated polymer essential for functional aggregation in gene regulation
SFPQ, (a.k.a. PSF), is a human tumor suppressor protein that regulates many important functions in the cell nucleus including coordination of long non-coding RNA molecule …
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