Analysis of normal theca cells treated with 500 uM valproic acid (VPA), an anti-epilipetic that induces polycystic ovary syndrome (PCOS)-like symptoms. Theca cells from PCOS patients also examined. Results provide insight into the underlying mechanisms contributing to VPA-induced PCOS-like symptoms.
GPL97:
[HG-U133B] Affymetrix Human Genome U133B Array
Citation:
Wood JR, Nelson-Degrave VL, Jansen E, McAllister JM et al. Valproate-induced alterations in human theca cell gene expression: clues to the association between valproate use and metabolic side effects. Physiol Genomics 2005 Feb 10;20(3):233-43. PMID: 15598877
