Macrophage response to lipopolysaccharide and CstF-64 overexpression
Summary:
Analysis of RAW 264.7 macrophages treated with 100 ng/ml lipopolysaccharide (LPS) for 18 hours, or overexpressing polyadenylation factor CstF-64. LPS treatment increases CstF-64 expression. Results provide insight into post-transcriptional mechanisms affected by LPS in macrophages.
Shell SA, Hesse C, Morris SM Jr, Milcarek C. Elevated levels of the 64-kDa cleavage stimulatory factor (CstF-64) in lipopolysaccharide-stimulated macrophages influence gene expression and induce alternative poly(A) site selection. J Biol Chem 2005 Dec 2;280(48):39950-61. PMID: 16207706
