Lipid peroxidation product 4-hydroxy-2-nonenal effect on cells: time course
Summary:
Analysis of RKO colorectal carcinoma cell line at 6 and 24 hours following exposure to subcytotoxic and cytotoxic amounts of 4-hydroxy-2-nonenal (HNE). HNE is an abundant product of polyunsaturated fatty acid oxidation and decomposition and reacts extensively with DNA and proteins.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
West JD, Marnett LJ. Alterations in gene expression induced by the lipid peroxidation product, 4-hydroxy-2-nonenal. Chem Res Toxicol 2005 Nov;18(11):1642-53. PMID: 16300372
