Thymocyte response to anti-T cell receptor antibody stimulation
Summary:
Analysis of CD4+CD8+ double positive thymocytes following engagement of T cell receptor (TCR) with anti-α-chain (aVα2) or β-chain (aVβ5) antibody. Results suggest aVα does not induce gene expression changes, whereas aVβ activates a transcriptional program that mimics positive thymic selection.
GPL81:
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array
Citation:
Niederberger N, Buehler LK, Ampudia J, Gascoigne NR. Thymocyte stimulation by anti-TCR-beta, but not by anti-TCR-alpha, leads to induction of developmental transcription program. J Leukoc Biol 2005 May;77(5):830-41. PMID: 15661827
