Analysis of lymph node (sinuses) and tonsil (no sinuses), highly similar secondary lymphoid organs. Metastatic tumor cells are preferentially arrested in the lymph node sinuses. Results identify signature genes that are prime candidates for mediating adhesion of tumor cells to sinusoidal cells.
GPL96:
[HG-U133A] Affymetrix Human Genome U133A Array
Citation:
Martens JH, Kzhyshkowska J, Falkowski-Hansen M, Schledzewski K et al. Differential expression of a gene signature for scavenger/lectin receptors by endothelial cells and macrophages in human lymph node sinuses, the primary sites of regional metastasis. J Pathol 2006 Mar;208(4):574-89. PMID: 16440291
