Quercetin effect on hepatic cytochrome P-450 oxidoreductase null mutants
Summary:
Analysis of cytochrome-P450 oxidoreductase (POR) null mutants at 24 hours following consumption of anti-carcinogenic flavonoid, quercetin. Results identify a diminished transcriptomic response in KO compared to WT in all tissues examined and provide insight into the bioactive nature of quercetin.
Mutch DM, Crespy V, Clough J, Henderson CJ et al. Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver. Am J Physiol Gastrointest Liver Physiol 2006 Jul;291(1):G63-72. PMID: 16455785
