Transcription factor Nrl deficiency effect on photoreceptor development
Summary:
Analysis of photoreceptors (PRs) from wild type and Nrl deficient retinas at various developmental stages. PRs isolated based on transgene GFP expression from an Nrl promoter. Nrl ablation leads to cones at the expense of rods. Results provide insight into the regulation of PR development.
Akimoto M, Cheng H, Zhu D, Brzezinski JA et al. Targeting of GFP to newborn rods by Nrl promoter and temporal expression profiling of flow-sorted photoreceptors. Proc Natl Acad Sci U S A 2006 Mar 7;103(10):3890-5. PMID: 16505381
