Caerulein effect on transcription factor Mist1 null pancreas
Summary:
Analysis of pancreas from transcription factor Mist1 knockouts (Mist1KO) injected with caerulein. Mist1KOs exhibit disrupted cell morphology in adult pancreatic acini; caerulein induces acute pancreatitis. Results identify genes that may contribute to susceptibility and initiation of pancreatitis.
Kowalik AS, Johnson CL, Chadi SA, Weston JY et al. Mice lacking the transcription factor Mist1 exhibit an altered stress response and increased sensitivity to caerulein-induced pancreatitis. Am J Physiol Gastrointest Liver Physiol 2007 Apr;292(4):G1123-32. PMID: 17170023
