Prostacylin receptor agonist and indomethacin effect on interleukin-1 beta activated synovial fibroblasts
Summary:
Analysis of interleukin-1 beta activated synovial fibroblasts following treatment with indomethacin, a non-steroidal anti-inflammatory drug, alone or in combination with iloprost, a prostacyclin (PGI) receptor agonist. Results provide insight into the role of PGI in rheumatoid arthritis.
Honda T, Segi-Nishida E, Miyachi Y, Narumiya S. Prostacyclin-IP signaling and prostaglandin E2-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis. J Exp Med 2006 Feb 20;203(2):325-35. PMID: 16446378
