Integrin beta-6 deficiency model of emphysema: alveolar macrophage
Summary:
Analysis of alveolar macrophages of integrin beta-6 (Itgb6) deficient animals treated with doxycycline. Itgb6 mutants develop emphysema. Effect of TGFbeta transgene induction to suppress the effect of the Itgb6 mutation also examined.
Woodruff PG, Koth LL, Yang YH, Rodriguez MW et al. A distinctive alveolar macrophage activation state induced by cigarette smoking. Am J Respir Crit Care Med 2005 Dec 1;172(11):1383-92. PMID: 16166618