Androgen receptor modulator effect: time course (HG-U133B)
Summary:
Analysis of LNCaP cells treated for 6 and 24 hours with RTI-018, an androgen receptor (AR) ligand with a mechanism of action different from that of canonical agonists. Results provide insight into the link between RTI-018 induced AR conformational changes and its ability to regulate gene expression.
GPL97:
[HG-U133B] Affymetrix Human Genome U133B Array
Citation:
Kazmin D, Prytkova T, Cook CE, Wolfinger R et al. Linking ligand-induced alterations in androgen receptor structure to differential gene expression: a first step in the rational design of selective androgen receptor modulators. Mol Endocrinol 2006 Jun;20(6):1201-17. PMID: 16574741
