DataSet Record GDS2289: Expression Profiles Data Analysis Tools Sample Subsets
Title: PPARalpha overexpression effect on skeletal muscles
Cluster AnalysisGDS2289 Cluster Image
Summary: Analysis of skeletal muscles of transgenics (trs) overexpressing PPARalpha. Trs overexpressing PPARalpha develop glucose intolerance despite protection from diet-induced obesity. Results provide insight into the role of PPARalpha in the development of insulin-resistant diabetes.
Organism: Mus musculus
Platform: GPL339: [MOE430A] Affymetrix Mouse Expression 430A Array
  • Finck BN, Bernal-Mizrachi C, Han DH, Coleman T et al. A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes. Cell Metab 2005 Feb;1(2):133-44. PMID: 16054054
  • Gan Z, Burkart-Hartman EM, Han DH, Finck B et al. The nuclear receptor PPARβ/δ programs muscle glucose metabolism in cooperation with AMPK and MEF2. Genes Dev 2011 Dec 15;25(24):2619-30. PMID: 22135324
Reference Series: GSE5777 Sample count: 4
Value type: count Series published: 2006/09/08