Akt1 serine-threonine protein kinase activation effect on the heart (MG-430B)
Summary:
Analysis of hearts after acute or chronic induction of a transgenic Akt1 kinase. Acute activation results in reversible hypertrophy, while chronic activation induces transition to failure. Results provide insight into the mechanisms involved in the development of cardiac hypertrophy and failure.
Schiekofer S, Shiojima I, Sato K, Galasso G et al. Microarray analysis of Akt1 activation in transgenic mouse hearts reveals transcript expression profiles associated with compensatory hypertrophy and failure. Physiol Genomics 2006 Oct 11;27(2):156-70. PMID: 16882883
