Analysis of ischemic cerebral cortices of ovariectomized animals on a regimen of 1 subcutaneous 17beta-estradiol pellet for 1 week. Ischemia was induced by middle cerebral artery occlusion. Results provide insight into the basis of estrogen's protective effect in experimental cerebral ischemia.
Xu Y, Zhang W, Klaus J, Young J et al. Role of cocaine- and amphetamine-regulated transcript in estradiol-mediated neuroprotection. Proc Natl Acad Sci U S A 2006 Sep 26;103(39):14489-94. PMID: 16971488
