Liver response to carcinogens that test positive in two-year rodent bioassays
Summary:
Analysis of livers of B6C3F1 females 13 weeks following treatment with chemicals that test positive in two-year rodent cancer bioassays. Results provide insight into the feasibility of using expression signatures, as alternatives to standard two-year bioassays, to identify chemical carcinogens.
Thomas RS, O'Connell TM, Pluta L, Wolfinger RD et al. A comparison of transcriptomic and metabonomic technologies for identifying biomarkers predictive of two-year rodent cancer bioassays. Toxicol Sci 2007 Mar;96(1):40-6. PMID: 17114358
