Analysis of cells exposed to the radiomimetic enediyne antibiotics calicheamicin, esperamicin A1, and neocarzinostatin. These enediynes bind specifically to DNA and generate single- and double-strand DNA breaks. Results provide insight into the response to DNA damage.
Fry RC, DeMott MS, Cosgrove JP, Begley TJ et al. The DNA-damage signature in Saccharomyces cerevisiae is associated with single-strand breaks in DNA. BMC Genomics 2006 Dec 12;7:313. PMID: 17163986