SOD1-G93A mutant model of amyotrophic lateral sclerosis: embryonic motor neurons
Summary:
Analysis of spinal cord motor neurons from embryonic day 14 transgenics expressing the human superoxide dismutase 1 (SOD1) G93A mutant protein. The SOD1-G93A transgenic is a model for amyotrophic lateral sclerosis (ALS). Results provide insight into the pathogenesis of ALS.
GPL1355:
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array
Citation:
Lobsiger CS, Boillée S, Cleveland DW. Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons. Proc Natl Acad Sci U S A 2007 May 1;104(18):7319-26. PMID: 17463094
